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    tmod tropomodulin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43633, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tmodprovided by FlyBase
    Official Full Name
    tropomodulinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0082582
    Locus tag
    Dmel_CG1539
    See related
    AllianceGenome:FB:FBgn0082582
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    1309/10; CG11493; CG1539; CG15540; CT3919; CT41421; Dmel\CG1539; E42; l(3)00848; l(3)S130910; spdo; Tmod
    Summary
    Predicted to enable tropomyosin binding activity. Predicted to be involved in actin filament organization and myofibril assembly. Located in fusome. Is active in M band. Is expressed in several structures, including anlage in statu nascendi; anterior-posterior subdivision of organism; endoderm anlage; gut section; and sensory nervous system primordium. Human ortholog(s) of this gene implicated in dilated cardiomyopathy 2G; megacystis-microcolon-intestinal hypoperistalsis syndrome; and nemaline myopathy 10. Orthologous to several human genes including TMOD1 (tropomodulin 1); TMOD2 (tropomodulin 2); and TMOD3 (tropomodulin 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See tmod in Genome Data Viewer
    Location:
    99F7-99F8; 3-100 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (30532607..30578905)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (26358329..26404627)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene jdp Neighboring gene long non-coding RNA:CR45552 Neighboring gene long non-coding RNA:CR45553 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Regulatory particle triple-A ATPase 6-related

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Thin filaments elongate from their pointed ends during myofibril assembly in Drosophila indirect flight muscle. Mardahl-Dumesnil M, et al. J Cell Biol, 2001 Dec 10. PMID 11739412, Free PMC Article
    2. Peripheral thickening of the sarcomeres and pointed end elongation of the thin filaments are both promoted by SALS and its formin interaction partners. Farkas D, et al. PLoS Genet, 2024 Jan. PMID 38198522, Free PMC Article
    3. Germline cyst formation and incomplete cytokinesis during Drosophila melanogaster oogenesis. Ong S, et al. Dev Biol, 2010 Jan 1. PMID 19850028
    4. The Drosophila formin Fhos is a primary mediator of sarcomeric thin-filament array assembly. Shwartz A, et al. Elife, 2016 Oct 12. PMID 27731794, Free PMC Article
    5. Apical Sarcomere-like Actomyosin Contracts Nonmuscle Drosophila Epithelial Cells. Coravos JS, et al. Dev Cell, 2016 Nov 7. PMID 27773487, Free PMC Article

    See all (82) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. E3 ubiquitin ligase neuralized is required for both Delta endocytosis and the internalization of Sanpodo
      Title: Regulation of membrane localization of Sanpodo by lethal giant larvae and neuralized in asymmetrically dividing cells of Drosophila sensory organs.
    2. Results suggest a model in which Numb inhibits Notch signaling through the regulation of Sanpodo membrane localization.
      Title: Numb inhibits membrane localization of Sanpodo, a four-pass transmembrane protein, to promote asymmetric divisions in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: 30533855-30533900 mobile_element_type = transposon:gypsy{}3516

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables tropomyosin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tropomyosin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in myofibril assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in pointed-end actin filament capping IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in M band IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell cortex HDA PubMed 
    is_active_in cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in fusome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in myofibril IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    tropomodulin
    Names
    CG1539-PA
    CG1539-PB
    CG1539-PC
    CG1539-PD
    CG1539-PE
    CG1539-PF
    CG1539-PG
    CG1539-PH
    CG1539-PI
    CG1539-PJ
    CG1539-PK
    CG1539-PL
    CG1539-PM
    CG1539-PN
    CG1539-PO
    CG1539-PP
    CG1539-PQ
    CG1539-PR
    sanpodo
    tmod-PA
    tmod-PB
    tmod-PC
    tmod-PD
    tmod-PE
    tmod-PF
    tmod-PG
    tmod-PH
    tmod-PI
    tmod-PJ
    tmod-PK
    tmod-PL
    tmod-PM
    tmod-PN
    tmod-PO
    tmod-PP
    tmod-PQ
    tmod-PR
    tropmodulin

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      30532607..30578905
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001170305.3 → NP_001163776.1  tropomodulin, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163776.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6IDG5, Q9VA59
      Conserved Domains (2) summary
      pfam03250
      Location:91 → 233
      Tropomodulin
      cl39015
      Location:285 → 421
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

    2. NM_001260442.2 → NP_001247371.1  tropomodulin, isoform M [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247371.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K7R6, Q6IDG5
      Conserved Domains (2) summary
      pfam03250
      Location:91 → 233
      Tropomodulin
      cl39015
      Location:285 → 421
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

    3. NM_001382033.1 → NP_001369033.1  tropomodulin, isoform R [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A6H2EEH6, Q6IDG5
      Conserved Domains (2) summary
      pfam03250
      Location:91 → 233
      Tropomodulin
      cl39015
      Location:285 → 421
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

    4. NM_001104512.4 → NP_001097982.1  tropomodulin, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097982.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8JRH3, Q6IDG5
      Conserved Domains (2) summary
      cd00116
      Location:285 → 421
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      pfam03250
      Location:91 → 233
      Tropomodulin; Tropomodulin

    5. NM_170504.4 → NP_733383.1  tropomodulin, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733383.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6IDG5, Q9VA59
      Related
      FBpp0085020
      Conserved Domains (2) summary
      pfam03250
      Location:91 → 233
      Tropomodulin
      cl39015
      Location:285 → 421
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

    6. NM_001202391.2 → NP_001189320.1  tropomodulin, isoform L [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001189320.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6IDG5, Q9VA59
      Conserved Domains (2) summary
      pfam03250
      Location:91 → 233
      Tropomodulin
      cl39015
      Location:285 → 421
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

    7. NM_170503.4 → NP_733382.1  tropomodulin, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733382.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6IDG5, Q9VA59
      Related
      FBpp0085021
      Conserved Domains (2) summary
      pfam03250
      Location:91 → 233
      Tropomodulin
      cl39015
      Location:285 → 421
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

    8. NM_001260443.2 → NP_001247372.1  tropomodulin, isoform N [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247372.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K6N4
      Conserved Domains (2) summary
      cd00116
      Location:285 → 421
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      pfam03250
      Location:91 → 233
      Tropomodulin; Tropomodulin

    9. NM_170505.4 → NP_733384.1  tropomodulin, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733384.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6IDG5, Q9VA59
      Related
      FBpp0085022
      Conserved Domains (2) summary
      pfam03250
      Location:91 → 233
      Tropomodulin
      cl39015
      Location:285 → 421
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

    10. NM_001276183.1 → NP_001263112.1  tropomodulin, isoform Q [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001263112.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KHW6, Q6IDG5
      Conserved Domains (2) summary
      pfam03250
      Location:91 → 233
      Tropomodulin
      cl39015
      Location:285 → 421
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

    11. NM_001276182.1 → NP_001263111.1  tropomodulin, isoform P [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001263111.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KHF2, Q6IDG5
      Conserved Domains (2) summary
      cd00116
      Location:285 → 434
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      pfam03250
      Location:91 → 233
      Tropomodulin; Tropomodulin

    12. NM_001170304.3 → NP_001163775.1  tropomodulin, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163775.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C8VV00, E1JJ21
      Conserved Domains (2) summary
      cd00116
      Location:218 → 301
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      pfam03250
      Location:24 → 166
      Tropomodulin; Tropomodulin

    13. NM_170506.3 → NP_733385.1  tropomodulin, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733385.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C8VV00, Q9VA58
      Related
      FBpp0085023
      Conserved Domains (2) summary
      cd00116
      Location:255 → 338
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      pfam03250
      Location:61 → 203
      Tropomodulin; Tropomodulin

    14. NM_001260444.2 → NP_001247373.1  tropomodulin, isoform O [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247373.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C7LAH8, C8VV00
      Conserved Domains (2) summary
      cd00116
      Location:255 → 338
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      pfam03250
      Location:61 → 203
      Tropomodulin; Tropomodulin

    15. NM_001202390.1 → NP_001189319.1  tropomodulin, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001189319.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C7LAH8, C8VV00
      Conserved Domains (2) summary
      cd00116
      Location:255 → 338
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      pfam03250
      Location:61 → 203
      Tropomodulin; Tropomodulin

    16. NM_001170306.2 → NP_001163777.1  tropomodulin, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163777.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C8VV00, Q9VA58
      Conserved Domains (2) summary
      cd00116
      Location:255 → 338
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      pfam03250
      Location:61 → 203
      Tropomodulin; Tropomodulin

    17. NM_057683.5 → NP_477031.1  tropomodulin, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477031.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C8VV00, O46231, Q9VA57
      Related
      FBpp0085024
      Conserved Domains (2) summary
      cd00116
      Location:213 → 296
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      pfam03250
      Location:19 → 161
      Tropomodulin; Tropomodulin

    18. NM_057684.4 → NP_477032.1  tropomodulin, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477032.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C8VV00, Q9VA56
      Related
      FBpp0085025
      Conserved Domains (2) summary
      pfam03250
      Location:55 → 197
      Tropomodulin
      cl39015
      Location:249 → 332
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4K6N4 A0A0B4K6N4
    A0A0B4K7R6 A0A0B4K7R6
    A0A0B4KHF2 A0A0B4KHF2
    A0A0B4KHW6 A0A0B4KHW6
    A0A6H2EEH6 A0A6H2EEH6
    A8JRH3 A8JRH3
    C7LAH8 C7LAH8
    E1JJ21 E1JJ21
    O46231 O46231
    Q9VA56 Q9VA56
    Q9VA58 Q9VA58
    Q9VA59 Q9VA59

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