tim timeless [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: timprovided by FlyBase
Official Full Name: timelessprovided by FlyBase
Primary source: FLYBASE:FBgn0014396
Locus tag: Dmel_CG3234
See related: AllianceGenome:FB:FBgn0014396
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG3234; Dmel\CG3234; dtim; dTim; dTIM; mel_tim; rit; Ritsu; s-tim; Tim; TIM; Tim-1; tim1
Summary: Predicted to enable DNA binding activity. Involved in several processes, including circadian temperature homeostasis; locomotor rhythm; and negative phototaxis. Located in cytosol and nucleus. Is expressed in several structures, including epithelium; gland; glial cell; organism subdivision; and pacemaker neurons. Used to study advanced sleep phase syndrome. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 23F6-23F6; 2-10 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (3493986..3508119, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (3493986..3508119, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Timeless noncoding DNA contains cell-type preferential enhancers important for proper Drosophila circadian regulation.
Title: Timeless noncoding DNA contains cell-type preferential enhancers important for proper Drosophila circadian regulation.
Cardiac Timeless Trans-Organically Regulated by miR-276 in Adipose Tissue Modulates Cardiac Function.
Title: Cardiac Timeless Trans-Organically Regulated by miR-276 in Adipose Tissue Modulates Cardiac Function.
Cryptochrome-Timeless structure reveals circadian clock timing mechanisms.
Title: Cryptochrome-Timeless structure reveals circadian clock timing mechanisms.
CLOCK and TIMELESS regulate rhythmic occupancy of the BRAHMA chromatin-remodeling protein at clock gene promoters.
Title: CLOCK and TIMELESS regulate rhythmic occupancy of the BRAHMA chromatin-remodeling protein at clock gene promoters.
Adaptation of Drosophila melanogaster to Long Photoperiods of High-Latitude Summers Is Facilitated by the ls-Timeless Allele.
Title: Adaptation of Drosophila melanogaster to Long Photoperiods of High-Latitude Summers Is Facilitated by the ls-Timeless Allele.
A natural timeless polymorphism allowing circadian clock synchronization in ""white nights"".
Title: A natural timeless polymorphism allowing circadian clock synchronization in "white nights".
Phosphatase of Regenerating Liver-1 Selectively Times Circadian Behavior in Darkness via Function in PDF Neurons and Dephosphorylation of TIMELESS.
Title: Phosphatase of Regenerating Liver-1 Selectively Times Circadian Behavior in Darkness via Function in PDF Neurons and Dephosphorylation of TIMELESS.
EYES ABSENT and TIMELESS integrate photoperiodic and temperature cues to regulate seasonal physiology in Drosophila.
Title: EYES ABSENT and TIMELESS integrate photoperiodic and temperature cues to regulate seasonal physiology in Drosophila.
PSI regulates the period of Drosophila circadian rhythms and circadian behavior phase during temperature cycling through its modulation of the tim splicing pattern.
Title: Drosophila PSI controls circadian period and the phase of circadian behavior under temperature cycle via tim splicing.
Data suggest that timeless (tim) alternative splicing might act as a thermometer for the circadian clock.
Title: Thermosensitive alternative splicing senses and mediates temperature adaptation in Drosophila.

Submit: New GeneRIF Correction See all GeneRIFs (49)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA repair	IBA Inferred from Biological aspect of Ancestor more info
involved_in DNA replication checkpoint signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to light stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in circadian behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in circadian regulation of heart rate	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in circadian temperature homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in copulation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in eclosion rhythm	TAS Traceable Author Statement more info	PubMed
involved_in entrainment of circadian clock	IBA Inferred from Biological aspect of Ancestor more info
involved_in entrainment of circadian clock	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in locomotor rhythm	IGI Inferred from Genetic Interaction more info	PubMed
involved_in locomotor rhythm	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mating behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative phototaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in photoperiodism	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of phagocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of circadian sleep/wake cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of circadian sleep/wake cycle, sleep	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of phagocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of protein import into nucleus	TAS Traceable Author Statement more info	PubMed
involved_in replication fork arrest	IBA Inferred from Biological aspect of Ancestor more info
involved_in rhythmic behavior	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of replication fork protection complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: timeless

Names: CG3234-PB; CG3234-PL; CG3234-PM; CG3234-PN; CG3234-PO; CG3234-PP; CG3234-PR; CG3234-PS; CG3234-PT; CG3234-PU; TIMELESS; bruchpilot; dtimeless; ritsu; tim-PB; tim-PL; tim-PM; tim-PN; tim-PO; tim-PP; tim-PR; tim-PS; tim-PT; tim-PU; timeless1