U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    sle slender lobes [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41262, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    sleprovided by FlyBase
    Official Full Name
    slender lobesprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037810
    Locus tag
    Dmel_CG12819
    See related
    AllianceGenome:FB:FBgn0037810
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG12819; CG12819-PA; Dmel\CG12819; FBtr0082231; Sle; SLE
    Summary
    Involved in nucleolus organization. Located in nucleolus. Colocalizes with spindle. Is expressed in several structures, including anterior endoderm; embryonic/larval midgut primordium; germline cell; gut section; and mesoderm. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See sle in Genome Data Viewer
    Location:
    86A8-86B1; 3-49 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (10333115..10338265)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (6158837..6163987)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene BIR repeat containing ubiquitin-conjugating enzyme Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Global analysis of RNA secondary structure in two metazoans. Li F, et al. Cell Rep, 2012 Jan 26. PMID 22832108
    2. Extremes of lineage plasticity in the Drosophila brain. Lin S, et al. Curr Biol, 2013 Oct 7. PMID 24055154, Free PMC Article
    3. Sex-specific effects of cis-regulatory variants in Drosophila melanogaster. Coolon JD, et al. Genetics, 2013 Dec. PMID 24097411, Free PMC Article
    4. The slender lobes gene, identified by retarded mushroom body development, is required for proper nucleolar organization in Drosophila. Orihara-Ono M, et al. Dev Biol, 2005 May 1. PMID 15848394
    5. Juvenile hormone membrane signaling phosphorylates USP and thus potentiates 20-hydroxyecdysone action in Drosophila. Gao Y, et al. Sci Bull (Beijing), 2022 Jan 30. PMID 36546012

    See all (63) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results suggest that slender lobes (sle) is a general factor of nuclear architecture in Drosophila that is required for the correct organization of the nucleolus during development.
      Title: The slender lobes gene, identified by retarded mushroom body development, is required for proper nucleolar organization in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in nucleolus organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    colocalizes_with spindle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    slender lobes
    Names
    CG12819-PA
    CG12819-PB
    sle-PA
    sle-PB
    slender lobe

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      10333115..10338265
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_169338.2 → NP_731472.1  slender lobes, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731472.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8INM3
      Related
      FBpp0081709
      Conserved Domains (1) summary
      COG5271
      Location:685 → 960
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

    2. NM_169339.2 → NP_731473.1  slender lobes, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731473.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q6NLK7, Q6YNC4, Q8INM3, Q95TF8, Q9VGZ9
      Related
      FBpp0081710
      Conserved Domains (1) summary
      COG5271
      Location:675 → 950
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8INM3.1 Q8INM3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools