U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    PTP-ER Protein tyrosine phosphatase-ERK/Enhancer of Ras1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37461, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    PTP-ERprovided by FlyBase
    Official Full Name
    Protein tyrosine phosphatase-ERK/Enhancer of Ras1provided by FlyBase
    Primary source
    FLYBASE:FBgn0016641
    Locus tag
    Dmel_CG9856
    See related
    AllianceGenome:FB:FBgn0016641
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9856; Dmel\CG9856; ER2-5; ptp-er
    Summary
    Enables MAP kinase phosphatase activity. Involved in mitotic cell cycle and negative regulation of ERK1 and ERK2 cascade. Located in cytoplasm. Is expressed in organism. Orthologous to human PTPN7 (protein tyrosine phosphatase non-receptor type 7). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See PTP-ER in Genome Data Viewer
    Location:
    57F4-57F4; 2-96 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (21619321..21624446, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (17506826..17511951, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene cricklet Neighboring gene mahjong Neighboring gene antisense RNA:CR42547 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Fisetin Exerts Antioxidant and Neuroprotective Effects in Multiple Mutant hSOD1 Models of Amyotrophic Lateral Sclerosis by Activating ERK. Wang TH, et al. Neuroscience, 2018 May 21. PMID 29559385
    2. ERK activation by the polyphenols fisetin and resveratrol provides neuroprotection in multiple models of Huntington's disease. Maher P, et al. Hum Mol Genet, 2011 Jan 15. PMID 20952447, Free PMC Article
    3. Pooled genome-wide CRISPR screening for basal and context-specific fitness gene essentiality in Drosophila cells. Viswanatha R, et al. Elife, 2018 Jul 27. PMID 30051818, Free PMC Article
    4. PTP-ER, a novel tyrosine phosphatase, functions downstream of Ras1 to downregulate MAP kinase during Drosophila eye development. Karim FD, et al. Mol Cell, 1999 Jun. PMID 10394362
    5. MKP-3 has essential roles as a negative regulator of the Ras/mitogen-activated protein kinase pathway during Drosophila development. Kim M, et al. Mol Cell Biol, 2004 Jan. PMID 14701731, Free PMC Article

    See all (58) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables MAP kinase phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables non-membrane spanning protein tyrosine phosphatase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of ERK1 and ERK2 cascade HGI PubMed 
    involved_in negative regulation of ERK1 and ERK2 cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    protein tyrosine phosphatase-ERK/Enhancer of Ras1
    Names
    CG9856-PA
    PTP-ER-PA
    protein tyrosine phosphatase
    protein tyrosine phosphatase- ERK/enhancer of RAS
    NP_726092.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      21619321..21624446 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_166465.2 → NP_726092.1  protein tyrosine phosphatase-ERK/Enhancer of Ras1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726092.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B3DNM2, Q9W2F3, Q9Y0X8
      Related
      FBpp0071603
      Conserved Domains (2) summary
      cd00047
      Location:917 → 1364
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      pfam00102
      Location:916 → 1364
      Y_phosphatase; Protein-tyrosine phosphatase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W2F3 Q9W2F3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous