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    obst-A obstructor-A [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33022, updated on 9-Dec-2024

    Summary

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    Official Symbol
    obst-Aprovided by FlyBase
    Official Full Name
    obstructor-Aprovided by FlyBase
    Primary source
    FLYBASE:FBgn0031097
    Locus tag
    Dmel_CG17052
    See related
    AllianceGenome:FB:FBgn0031097
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG17052; Dmel\CG17052; obst; Obst-A; ObstA
    Summary
    Enables chitin binding activity. A structural constituent of chitin-based cuticle. Involved in larval chitin-based cuticle development; negative regulation of extracellular matrix disassembly; and regulation of tube size, open tracheal system. Located in chitin-based extracellular matrix. Is expressed in several structures, including embryonic epipharynx; embryonic/larval spiracle primordium; epithelium; gut section; and primary segmental tracheal branch primordium. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See obst-A in Genome Data Viewer
    Location:
    19C1-19C1; 1-64 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (20239855..20243209)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (20110929..20114283)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene short wing Neighboring gene long non-coding RNA:CR45465 Neighboring gene Peritrophin A Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Control of airway tube diameter and integrity by secreted chitin-binding proteins in Drosophila. Tiklová K, et al. PLoS One, 2013. PMID 23826295, Free PMC Article
    2. Obstructor A organizes matrix assembly at the apical cell surface to promote enzymatic cuticle maturation in Drosophila. Pesch YY, et al. J Biol Chem, 2015 Apr 17. PMID 25737451, Free PMC Article
    3. Obstructor-A is required for epithelial extracellular matrix dynamics, exoskeleton function, and tubulogenesis. Petkau G, et al. J Biol Chem, 2012 Jun 15. PMID 22544743, Free PMC Article
    4. Shaping of biological tubes by mechanical interaction of cell and extracellular matrix. Dong B, et al. Curr Opin Genet Dev, 2015 Jun. PMID 25819978
    5. rebuff regulates apical luminal matrix to control tube size in Drosophila trachea. Chandran RR, et al. Biol Open, 2018 Sep 5. PMID 30185423, Free PMC Article

    See all (53) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Obstructor A organizes matrix assembly at the apical cell surface to promote enzymatic cuticle maturation in Drosophila.
      Title: Obstructor A organizes matrix assembly at the apical cell surface to promote enzymatic cuticle maturation in Drosophila.
    2. The evolutionary conservation suggests a common role of Obstructor-A and homologs in coordinating extracellular matrix protection in epithelial tissues of chitinous invertebrates.
      Title: Obstructor-A is required for epithelial extracellular matrix dynamics, exoskeleton function, and tubulogenesis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables chitin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables chitin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of chitin-based cuticle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chitin-based cuticle development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in larval chitin-based cuticle development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of extracellular matrix disassembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of tube size, open tracheal system IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chitin-based extracellular matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    obstructor-A
    Names
    CG17052-PA
    CG17052-PB
    Obstructor-A
    obst-A-PA
    obst-A-PB
    obstructor

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      20239855..20243209
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_134534.3 → NP_608378.2  obstructor-A, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608378.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VR79
      Related
      FBpp0077026
      Conserved Domains (1) summary
      pfam01607
      Location:180 → 225
      CBM_14; Chitin binding Peritrophin-A domain

    2. NM_001258849.2 → NP_001245778.1  obstructor-A, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245778.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VR79
      Conserved Domains (1) summary
      pfam01607
      Location:180 → 225
      CBM_14; Chitin binding Peritrophin-A domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VR79 Q9VR79

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
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