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    CG5196 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41522, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG5196provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0038039
    Locus tag
    Dmel_CG5196
    See related
    AllianceGenome:FB:FBgn0038039
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG5196
    Summary
    Predicted to enable protein-cysteine S-palmitoyltransferase activity. Predicted to be involved in protein targeting to membrane. Located in endoplasmic reticulum. Is expressed in several structures, including adult head; dorsal sensory complex primordium; embryonic head sensory system; embryonic/larval garland cell; and sensory nervous system primordium. Orthologous to human ZDHHC6 (zinc finger DHHC-type palmitoyltransferase 6). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG5196 in Genome Data Viewer
    Location:
    87B9-87B9; 3-52 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (12408316..12411768)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (8234038..8237490)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Cytochrome P450 9f2 Neighboring gene uncharacterized protein Neighboring gene Dipeptidase C Neighboring gene small non-coding RNA 649 Neighboring gene protein partner of snf Neighboring gene Sarcoglycan beta

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Membrane targeting of inhibitory Smads through palmitoylation controls TGF-β/BMP signaling. Li W, et al. Proc Natl Acad Sci U S A, 2017 Dec 12. PMID 29180412, Free PMC Article
    2. Generating customized transgene landing sites and multi-transgene arrays in Drosophila using phiC31 integrase. Knapp JM, et al. Genetics, 2015 Apr. PMID 25680812, Free PMC Article
    3. The S-palmitoylome and DHHC-PAT interactome of Drosophila melanogaster S2R+ cells indicate a high degree of conservation to mammalian palmitoylomes. Porcellato E, et al. PLoS One, 2022. PMID 35960718, Free PMC Article
    4. Mapping Quantitative Trait Loci Underlying Circadian Light Sensitivity in Drosophila. Adewoye AB, et al. J Biol Rhythms, 2017 Oct. PMID 28990443
    5. Gain of function screen of PATs reveals an essential role of Hip14 in Drosophila host defense. Deng Z, et al. J Genet Genomics, 2023 Dec. PMID 37343788

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables palmitoyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-cysteine S-palmitoyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-cysteine S-palmitoyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein targeting to membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endomembrane system HDA PubMed 
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG5196-PA
    CG5196-PB
    NP_650191.1
    NP_996201.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      12408316..12411768
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141934.2 → NP_650191.1  uncharacterized protein Dmel_CG5196, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650191.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VG80
      Related
      FBpp0082056
      Conserved Domains (1) summary
      pfam01529
      Location:89 → 223
      zf-DHHC; DHHC palmitoyltransferase

    2. NM_206479.2 → NP_996201.1  uncharacterized protein Dmel_CG5196, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996201.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SWX8
      Conserved Domains (1) summary
      pfam01529
      Location:57 → 191
      zf-DHHC; DHHC palmitoyltransferase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8SWX8 Q8SWX8
    Q9VG80 Q9VG80

    Gene LinkOut

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