Idgf3 Imaginal disc growth factor 3 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Idgf3provided by FlyBase
Official Full Name: Imaginal disc growth factor 3provided by FlyBase
Primary source: FLYBASE:FBgn0020414
Locus tag: Dmel_CG4559
See related: AllianceGenome:FB:FBgn0020414
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: BG:DS02780.2; CG4559; Dmel\CG4559; DmIDGF3; FBgn0020414; IDGF; IDGF-3; idgf3; IDGF3; lincRNA.163
Summary: Enables imaginal disc growth factor receptor binding activity. Involved in several processes, including chitin-based cuticle development; ecdysis, chitin-based cuticle; and regulation of chitin metabolic process. Located in extracellular region. Is expressed in several structures, including adult head; amnioproctodeal invagination; epithelial furrow; female germline cell; and visceral mesoderm derivative. Human ortholog(s) of this gene implicated in asthma and schizophrenia. Orthologous to several human genes including CHIT1 (chitinase 1); CHI3L1 (chitinase 3 like 1); and CHI3L2 (chitinase 3 like 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 36A1-36A1; 2-52 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (16450907..16455194)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (16450907..16455194)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Detecting New Allies: Modifier Screen Identifies a Genetic Interaction Between Imaginal disc growth factor 3 and combover, a Rho-kinase Substrate, During Dorsal Appendage Tube Formation in Drosophila.
Title: Detecting New Allies: Modifier Screen Identifies a Genetic Interaction Between Imaginal disc growth factor 3 and combover, a Rho-kinase Substrate, During Dorsal Appendage Tube Formation in Drosophila.
The results indicate that Idgf2 and Idgf3 might be involved in different yet crucial immune functions in the Drosophila anti-nematode immune response. Idgf2 and Idgf3 modulate distinct immune functions in Drosophila larvae in response to Steinernema nematode infection.
Title: The Imaginal Disc Growth Factors 2 and 3 participate in the Drosophila response to nematode infection.
IDGF3 has multiple roles in innate immunity. It serves as an essential component required for the formation of hemolymph clots that seal wounds, and Idgf3 mutants display an extended developmental delay during wound healing.
Title: The Drosophila Chitinase-Like Protein IDGF3 Is Involved in Protection against Nematodes and in Wound Healing.
determination of polymorphism patterns
Title: Polymorphism patterns in two tightly linked developmental genes, Idgf1 and Idgf3, of Drosophila melanogaster.

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General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables chitin binding	IEA Inferred from Electronic Annotation more info
enables imaginal disc growth factor receptor binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in chitin catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in chitin-based cuticle development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ecdysis, chitin-based cuticle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc development	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of chitin metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in wound healing	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	HDA more info	PubMed
is_active_in extracellular region	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: imaginal disc growth factor 3

Names: CG4559-PA; CG4559-PB; CG4559-PC; CG4559-PD; Idgf3-PA; Idgf3-PB; Idgf3-PC; Idgf3-PD

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

16450907..16455194

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_165158.1 → NP_723967.1 imaginal disc growth factor 3, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_723967.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V0S4, O96666, Q8MLZ7, Q8MM23, Q8MX33, Q8MX34, Q8MX35, Q8MX36, Q8MX37, Q8MX38, Q8MX39, Q9V3B9

UniProtKB/TrEMBL

X2JA18

Related

FBpp0080419, FBtr0080862

Conserved Domains (2) summary

cd02873
Location:26 → 440

GH18_IDGF; The IDGF's (imaginal disc growth factors) are a family of growth factors identified in insects that include at least five members, some of which are encoded by genes in a tight cluster. The IDGF's have an eight-stranded alpha/beta barrel fold and are ...

smart00636
Location:27 → 419

Glyco_18; Glyco_18 domain
NM_001299053.1 → NP_001285982.1 imaginal disc growth factor 3, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001285982.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V0S4, O96666, Q8MLZ7, Q8MM23, Q8MX33, Q8MX34, Q8MX35, Q8MX36, Q8MX37, Q8MX38, Q8MX39, Q9V3B9

UniProtKB/TrEMBL

X2JA18

Conserved Domains (2) summary

cd02873
Location:26 → 440

GH18_IDGF; The IDGF's (imaginal disc growth factors) are a family of growth factors identified in insects that include at least five members, some of which are encoded by genes in a tight cluster. The IDGF's have an eight-stranded alpha/beta barrel fold and are ...

smart00636
Location:27 → 419

Glyco_18; Glyco_18 domain
NM_165157.2 → NP_723966.1 imaginal disc growth factor 3, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_723966.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V0S4, O96666, Q8MLZ7, Q8MM23, Q8MX33, Q8MX34, Q8MX35, Q8MX36, Q8MX37, Q8MX38, Q8MX39, Q9V3B9

UniProtKB/TrEMBL

X2JA18

Related

FBpp0080420

Conserved Domains (2) summary

cd02873
Location:26 → 440

GH18_IDGF; The IDGF's (imaginal disc growth factors) are a family of growth factors identified in insects that include at least five members, some of which are encoded by genes in a tight cluster. The IDGF's have an eight-stranded alpha/beta barrel fold and are ...

smart00636
Location:27 → 419

Glyco_18; Glyco_18 domain
NM_057908.4 → NP_477256.1 imaginal disc growth factor 3, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_477256.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V0S4, O96666, Q8MLZ7, Q8MM23, Q8MX33, Q8MX34, Q8MX35, Q8MX36, Q8MX37, Q8MX38, Q8MX39, Q9V3B9

UniProtKB/TrEMBL

X2JA18

Related

FBpp0080421

Conserved Domains (2) summary

cd02873
Location:26 → 440

GH18_IDGF; The IDGF's (imaginal disc growth factors) are a family of growth factors identified in insects that include at least five members, some of which are encoded by genes in a tight cluster. The IDGF's have an eight-stranded alpha/beta barrel fold and are ...

smart00636
Location:27 → 419

Glyco_18; Glyco_18 domain