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    CG5888 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34980, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG5888provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0028523
    Locus tag
    Dmel_CG5888
    See related
    AllianceGenome:FB:FBgn0028523
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BG:DS02780.1; CT18477; Dmel\CG5888
    Summary
    Predicted to enable potassium channel activator activity; transmembrane transporter binding activity; and voltage-gated potassium channel activity. Predicted to be part of voltage-gated potassium channel complex. Is expressed in several structures, including central brain primordium; dorsal ectoderm anlage; embryonic optic lobe primordium; hindgut anlage; and hindgut anlage in statu nascendi. Orthologous to human LRRC26 (leucine rich repeat containing 26) and LRRC52 (leucine rich repeat containing 52). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG5888 in Genome Data Viewer
    Location:
    35F12-36A1; 2-52 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (16400175..16448469, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (16400175..16448469, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene calcium-binding protein 1 Neighboring gene juvenile hormone acid methyltransferase Neighboring gene Imaginal disc growth factor 1 Neighboring gene Imaginal disc growth factor 2 Neighboring gene Imaginal disc growth factor 3 Neighboring gene dachshund

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Widespread activation of developmental gene expression characterized by PRC1-dependent chromatin looping. Loubiere V, et al. Sci Adv, 2020 Jan. PMID 31950077, Free PMC Article
    2. Rough eye is a gain-of-function allele of amos that disrupts regulation of the proneural gene atonal during Drosophila retinal differentiation. Chanut F, et al. Genetics, 2002 Feb. PMID 11861566, Free PMC Article
    3. Amplification of the 1731 LTR retrotransposon in Drosophila melanogaster cultured cells: origin of neocopies and impact on the genome. Maisonhaute C, et al. Gene, 2007 May 15. PMID 17382490
    4. Coupling of zygotic transcription to mitotic control at the Drosophila mid-blastula transition. Lu X, et al. Development, 2009 Jun. PMID 19465600, Free PMC Article
    5. A natural genetic variation screen identifies insulin signaling, neuronal communication, and innate immunity as modifiers of hyperglycemia in the absence of Sirt1. Palu RAS, et al. G3 (Bethesda), 2022 May 30. PMID 35435227, Free PMC Article

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG5888-PA
    CG5888-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      16400175..16448469 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135950.3 → NP_609794.1  uncharacterized protein Dmel_CG5888, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609794.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1NZE7, Q7KT58
      Related
      FBpp0080437
      Conserved Domains (2) summary
      sd00033
      Location:168 → 189
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:288 → 348
      LRR_8; Leucine rich repeat

    2. NM_001299052.1 → NP_001285981.1  uncharacterized protein Dmel_CG5888, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285981.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1NZE7, Q7KT58
      Conserved Domains (2) summary
      sd00033
      Location:168 → 189
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:288 → 348
      LRR_8; Leucine rich repeat
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7KT58 Q7KT58

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