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    ninaA neither inactivation nor afterpotential A [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33271, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ninaAprovided by FlyBase
    Official Full Name
    neither inactivation nor afterpotential Aprovided by FlyBase
    Primary source
    FLYBASE:FBgn0002936
    Locus tag
    Dmel_CG3966
    See related
    AllianceGenome:FB:FBgn0002936
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3966; Dmel\CG3966; ninA; NinaA; NINAA
    Summary
    Enables cyclosporin A binding activity. Involved in N-glycan processing; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; and rhodopsin biosynthetic process. Located in cytoplasmic vesicle; endoplasmic reticulum lumen; and endoplasmic reticulum membrane. Is expressed in Bolwig organ; adult head; and eye. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ninaA in Genome Data Viewer
    Location:
    21E2-21E2; 2-1.5 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (877302..878270)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (877302..878270)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene dribble Neighboring gene Phosphatase 1 nuclear targeting subunit Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45348 Neighboring gene Larval serum protein 1 beta

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The ninaA gene required for visual transduction in Drosophila encodes a homologue of cyclosporin A-binding protein. Shieh BH, et al. Nature, 1989 Mar 2. PMID 2493138
    2. Drosophila ninaA gene encodes an eye-specific cyclophilin (cyclosporine A binding protein). Schneuwly S, et al. Proc Natl Acad Sci U S A, 1989 Jul. PMID 2664782, Free PMC Article
    3. Photoreceptor function. Pak WL, et al. Basic Life Sci, 1980. PMID 6779798
    4. Mutation that selectively affects rhodopsin concentration in the peripheral photoreceptors of Drosophila melanogaster. Larrivee DC, et al. J Gen Physiol, 1981 Nov. PMID 6796648, Free PMC Article
    5. Proline isomerases in microorganisms and small eukaryotes. Hemenway C, et al. Ann N Y Acad Sci, 1993 Nov 30. PMID 8109845

    See all (105) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables cyclosporin A binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cyclosporin A binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables peptidyl-prolyl cis-trans isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptidyl-prolyl cis-trans isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidyl-prolyl cis-trans isomerase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in 'de novo' protein folding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in N-glycan processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein folding IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein peptidyl-prolyl isomerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in rhodopsin biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in rhodopsin biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum lumen IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    neither inactivation nor afterpotential A
    Names
    CG3966-PA
    either inactivation nor afterpotential A
    neither inactivation nor after potential
    ninaA-PA
    NP_476656.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      877302..878270
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057308.4 → NP_476656.1  neither inactivation nor afterpotential A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476656.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P15425, Q9VPV0
      UniProtKB/TrEMBL
      Q540W6
      Related
      FBpp0077688
      Conserved Domains (1) summary
      cl00197
      Location:27 → 189
      cyclophilin; cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P15425.1 P15425
    Q540W6 Q540W6

    Gene LinkOut

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