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    trbd trabid [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41179, updated on 9-Dec-2024

    Summary

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    Official Symbol
    trbdprovided by FlyBase
    Official Full Name
    trabidprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037734
    Locus tag
    Dmel_CG9448
    See related
    AllianceGenome:FB:FBgn0037734
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9448; Dmel\CG9448; dTrbd; Q9VH90; Trabid; Trbd
    Summary
    Enables K63-linked deubiquitinase activity. Involved in negative regulation of peptidoglycan recognition protein signaling pathway and positive regulation of canonical Wnt signaling pathway. Predicted to be active in cytoplasm and nucleus. Is expressed in embryonic dorsal epidermis; embryonic foregut; embryonic ventral epidermis; and organism. Orthologous to human ZRANB1 (zinc finger RANBP2-type containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See trbd in Genome Data Viewer
    Location:
    85E5-85E5; 3-49 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (9705996..9711037, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (5531718..5536759, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Uncoordinated 115b Neighboring gene p24-related-2 Neighboring gene uncharacterized protein Neighboring gene Uncoordinated 115a Neighboring gene small Cajal body-specific RNA : PsiU1-6 Neighboring gene dalmatian Neighboring gene hyperplastic discs

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Interaction Between Familial Transmission and a Constitutively Active Immune System Shapes Gut Microbiota in Drosophila melanogaster. Mistry R, et al. Genetics, 2017 Jun. PMID 28413160, Free PMC Article
    2. DnaJ-1 and karyopherin α3 suppress degeneration in a new Drosophila model of Spinocerebellar Ataxia Type 6. Tsou WL, et al. Hum Mol Genet, 2015 Aug 1. PMID 25954029, Free PMC Article
    3. A Feedback Regulatory Loop Involving dTrbd/dTak1 in Controlling IMD Signaling in Drosophila Melanogaster. Hua Y, et al. Front Immunol, 2022. PMID 35911722, Free PMC Article
    4. A novel superfamily of predicted cysteine proteases from eukaryotes, viruses and Chlamydia pneumoniae. Makarova KS, et al. Trends Biochem Sci, 2000 Feb. PMID 10664582
    5. Evolutionary Loss of Activity in De-Ubiquitylating Enzymes of the OTU Family. Louis M, et al. PLoS One, 2015. PMID 26588485, Free PMC Article

    See all (55) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The TAK1-associated Binding Protein 2 (TAB2) was linked with the TAK1-Trabid interaction through its Zinc finger domain that pacified the TAK1 signal
      Title: Loss of Trabid, a new negative regulator of the drosophila immune-deficiency pathway at the level of TAK1, reduces life span.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables K63-linked deubiquitinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables K63-linked deubiquitinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables K63-linked polyubiquitin modification-dependent protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type deubiquitinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of peptidoglycan recognition protein signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of canonical Wnt signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein K63-linked deubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein deubiquitination involved in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    trabid
    Names
    CG9448-PA
    trbd-PA
    NP_649931.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      9705996..9711037 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141674.3 → NP_649931.1  trabid [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649931.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8T9K1, Q9VH90
      Related
      FBpp0081569
      Conserved Domains (5) summary
      smart00547
      Location:234 → 256
      ZnF_RBZ; Zinc finger domain
      sd00025
      Location:175 → 192
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      sd00029
      Location:11 → 30
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      pfam00641
      Location:11 → 36
      zf-RanBP; Zn-finger in Ran binding protein and others
      pfam02338
      Location:513 → 659
      OTU; OTU-like cysteine protease
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VH90.1 Q9VH90

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
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