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    Mgat1 Mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37323, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mgat1provided by FlyBase
    Official Full Name
    Mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034521
    Locus tag
    Dmel_CG13431
    See related
    AllianceGenome:FB:FBgn0034521
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG13431; Dmel\CG13431; dMGAT1; GlcNAc-TI; GlcNAcT1; GlcNAcTI; MGAT; mgat1; MGAT1
    Summary
    Enables alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity. Involved in several processes, including brain development; determination of adult lifespan; and protein N-linked glycosylation via asparagine. Located in Golgi medial cisterna. Is expressed in adult head. Orthologous to human MGAT1 (alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Mgat1 in Genome Data Viewer
    Location:
    57A5-57A5; 2-91 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (20559156..20562331, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (16446661..16449836, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Cuticular protein 57A Neighboring gene Odorant-binding protein 57d Neighboring gene uncharacterized protein Neighboring gene BLOC-1 related complex subunit 7 Neighboring gene lateral muscles scarcer Neighboring gene antisense RNA:CR44653 Neighboring gene uncharacterized protein Neighboring gene quasimodo

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. N-glycosylation requirements in neuromuscular synaptogenesis. Parkinson W, et al. Development, 2013 Dec. PMID 24227656, Free PMC Article
    2. Neuronal expression of Mgat1 rescues the shortened life span of Drosophila Mgat11 null mutants and increases life span. Sarkar M, et al. Proc Natl Acad Sci U S A, 2010 May 25. PMID 20457894, Free PMC Article
    3. Cloning and expression of Drosophila melanogaster UDP-GlcNAc:alpha-3-D-mannoside beta1,2-N-acetylglucosaminyltransferase I. Sarkar M, et al. Biol Chem, 2001 Feb. PMID 11308019
    4. Point mutations that inactivate MGAT4D-L, an inhibitor of MGAT1 and complex N-glycan synthesis. Akintayo A, et al. J Biol Chem, 2020 Oct 9. PMID 32763972, Free PMC Article
    5. Null mutations in Drosophila N-acetylglucosaminyltransferase I produce defects in locomotion and a reduced life span. Sarkar M, et al. J Biol Chem, 2006 May 5. PMID 16522637

    See all (53) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Point mutations that inactivate MGAT4D-L, an inhibitor of MGAT1 and complex N-glycan synthesis.
      Title: Point mutations that inactivate MGAT4D-L, an inhibitor of MGAT1 and complex N-glycan synthesis.
    2. MGAT1-dependent N-glycosylation shapes the synaptomatrix carbohydrate environment and endogenous lectin localization within this domain, to modulate retention of trans-synaptic signaling ligands driving synaptic scaffold recruitment during synaptogenesis.
      Title: N-glycosylation requirements in neuromuscular synaptogenesis.
    3. show that knockdown of Mgat1 in the central nervous system (CNS) of wild-type flies decreases locomotor activity and life span.
      Title: Neuronal expression of Mgat1 rescues the shortened life span of Drosophila Mgat11 null mutants and increases life span.
    4. beta1,2-N-acetylglucosaminyltransferase I-dependent N-glycans are required for locomotory activity, life span, and brain development in Drosophila
      Title: Null mutations in Drosophila N-acetylglucosaminyltransferase I produce defects in locomotion and a reduced life span.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables acetylglucosaminyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables acetylglucosaminyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in adult locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in brain segmentation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in encapsulation of foreign target IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mushroom body development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein N-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein N-linked glycosylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein N-linked glycosylation via asparagine IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi medial cisterna IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
    Names
    CG13431-PA
    Mgat1-PA
    N-acetylglucosaminyltransferase I
    UDP-GlcNAc:a-3-D-mannoside-beta-1,2-N-acetylglucosaminyltransferase I
    mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase 1
    NP_525117.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      20559156..20562331 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_080378.4 → NP_525117.2  mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_525117.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q60GL7, Q9NGK4
      Related
      FBpp0085571
      Conserved Domains (1) summary
      cd02514
      Location:119 → 449
      GT13_GLCNAC-TI; GT13_GLCNAC-TI is involved in an essential step in the synthesis of complex or hybrid-type N-linked oligosaccharides
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q60GL7 Q60GL7
    Q95SE9 Q95SE9
    Q9NGK4 Q9NGK4

    Gene LinkOut

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