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    twr twisted bristles roughened eye [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40815, updated on 9-Dec-2024

    Summary

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    Official Symbol
    twrprovided by FlyBase
    Official Full Name
    twisted bristles roughened eyeprovided by FlyBase
    Primary source
    FLYBASE:FBgn0262801
    Locus tag
    Dmel_CG2358
    See related
    AllianceGenome:FB:FBgn0262801
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    AF160889; BcDNA:GM04682; BG:DS00004.11; CG2358; Dmel\CG2358; EfW5; l(3)05614; l(3)84Aa; Ov15; Spase18-21; Spase18/21
    Summary
    Enables serine hydrolase activity. Predicted to be involved in signal peptide processing. Located in endomembrane system. Is expressed in several structures, including adult head; embryonic/larval midgut primordium; gland; gut section; and mesoderm. Orthologous to several human genes including SEC11A (SEC11 homolog A, signal peptidase complex subunit). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See twr in Genome Data Viewer
    Location:
    84A1-84A1; 3-48 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (6657882..6659442)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (2483604..2485164)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Argininosuccinate synthase Neighboring gene TBP-associated factor 1 Neighboring gene uncharacterized protein Neighboring gene O-6-alkylguanine-DNA alkyltransferase Neighboring gene labial Neighboring gene Ecdysone-dependent gene 84A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Rapid identification of heterozygous mutations in Drosophila melanogaster using genomic capture sequencing. Wang H, et al. Genome Res, 2010 Jul. PMID 20472684, Free PMC Article
    2. Analysis of the functions of the signal peptidase complex in the midgut of Tribolium castaneum. Guan J, et al. Arch Insect Biochem Physiol, 2018 Mar. PMID 29265467
    3. Fine-scale genetic mapping of a hybrid sterility factor between Drosophila simulans and D. mauritiana: the varied and elusive functions of "speciation genes". Araripe LO, et al. BMC Evol Biol, 2010 Dec 14. PMID 21144061, Free PMC Article
    4. Genetic Analysis of the Antennapedia Gene Complex (Ant-C) and Adjacent Chromosomal Regions of DROSOPHILA MELANOGASTER. II. Polytene Chromosome Segments 84A-84B1,2. Lewis RA, et al. Genetics, 1980 Jun. PMID 17249042, Free PMC Article
    5. Revertants of Dominant Mutations Associated with the Antennapedia Gene Complex of DROSOPHILA MELANOGASTER: Cytology and Genetics. Hazelrigg T, et al. Genetics, 1983 Nov. PMID 17246168, Free PMC Article

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables peptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables serine hydrolase activity HDA PubMed 
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in signal peptide processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal peptide processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal peptide processing ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in endomembrane system HDA PubMed 
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of signal peptidase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of signal peptidase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    twisted bristles roughened eye
    Names
    CG2358-PA
    SPC 21-kDa-like
    SPase 18/21-subunit
    twr-PA
    NP_649676.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      6657882..6659442
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141419.4 → NP_649676.1  twisted bristles roughened eye [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649676.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O97066, Q3YMT4
      Related
      FBpp0081185
      Conserved Domains (1) summary
      cl10465
      Location:28 → 181
      Peptidase_S24_S26; The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O97066 O97066
    Q3YMT4 Q3YMT4

    Gene LinkOut

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