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    scaf6 SR-related CTD associated factor 6 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 3346235, updated on 9-Dec-2024

    Summary

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    Official Symbol
    scaf6provided by FlyBase
    Official Full Name
    SR-related CTD associated factor 6provided by FlyBase
    Primary source
    FLYBASE:FBgn0261872
    Locus tag
    Dmel_CG33522
    See related
    AllianceGenome:FB:FBgn0261872
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BP1040; BP1047; CG14058; CG32168; CG33522; CG6615; CG6626; Dmel\CG33522
    Summary
    Predicted to enable RNA binding activity. Predicted to be involved in intracellular calcium ion homeostasis. Predicted to be active in perinuclear region of cytoplasm. Is expressed in several structures, including central brain primordium; ganglia; larval nervous system; and ventral nerve cord primordium. Orthologous to human CHERP (calcium homeostasis endoplasmic reticulum protein). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See scaf6 in Genome Data Viewer
    Location:
    73E5-73E5; 3-45 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (17036859..17042574, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (17029959..17035674, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45756 Neighboring gene Insulin-like peptide 8 Neighboring gene long non-coding RNA:CR43250 Neighboring gene bad egg Neighboring gene PAPS transporter 2 Neighboring gene POP5 ribonuclease P/MRP subunit Neighboring gene Troponin C at 73F

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A genetic screen based on in vivo RNA imaging reveals centrosome-independent mechanisms for localizing gurken transcripts in Drosophila. Hayashi R, et al. G3 (Bethesda), 2014 Apr 16. PMID 24531791, Free PMC Article
    2. Brain Proteome of Drosophila melanogaster Is Enriched with Nuclear Proteins. Kuznetsova KG, et al. Biochemistry (Mosc), 2019 Jan. PMID 30927528
    3. The Drosophila melanogaster Genetic Reference Panel. Mackay TF, et al. Nature, 2012 Feb 8. PMID 22318601, Free PMC Article
    4. A computational and experimental approach to validating annotations and gene predictions in the Drosophila melanogaster genome. Yandell M, et al. Proc Natl Acad Sci U S A, 2005 Feb 1. PMID 15668397, Free PMC Article
    5. Identification of proteasome components required for apical localization of Chaoptin using functional genomics. Yano H, et al. J Neurogenet, 2012 Mar. PMID 22417167

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular calcium ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular calcium ion homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in perinuclear region of cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    SR-related CTD associated factor 6
    Names
    BP1047
    CG33522-PA
    CG33522-PC
    CG33522-PE
    scaf6-PA
    scaf6-PC
    scaf6-PE

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      17036859..17042574 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001038939.2 → NP_001034028.2  SR-related CTD associated factor 6, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001034028.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A023GQ04
      Conserved Domains (1) summary
      pfam01805
      Location:13 → 61
      Surp; Surp module

    2. NM_001014589.4 → NP_001014589.1  SR-related CTD associated factor 6, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001014589.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q59E33, Q8I9J8
      Conserved Domains (3) summary
      pfam01585
      Location:885 → 933
      G-patch; G-patch domain
      pfam01805
      Location:13 → 61
      Surp; Surp module
      pfam04818
      Location:271 → 329
      CTD_bind; RNA polymerase II-binding domain

    3. NM_001169986.3 → NP_001163457.1  SR-related CTD associated factor 6, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163457.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86MQ9
      Conserved Domains (1) summary
      pfam01805
      Location:13 → 61
      Surp; Surp module
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A023GQ04 A0A023GQ04
    Q59E33 Q59E33
    Q7K2G6 Q7K2G6
    Q86MQ9 Q86MQ9
    Q8I9J8 Q8I9J8

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