bsk basket [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: bskprovided by FlyBase
Official Full Name: basketprovided by FlyBase
Primary source: FLYBASE:FBgn0000229
Locus tag: Dmel_CG5680
See related: AllianceGenome:FB:FBgn0000229
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: Basket; Bsk; BSK; bsk/JNK; CG5680; D-JNK; D-junk; DBSK/JNK; dJnk; dJNK; DJNK; DJNK/bsk; Dmel\CG5680; DmJNK; dNJNK; Jak; JAK; jnk; Jnk; JNK; jnk (bsk); JNK/SAPK; Junk; p-JNK; P-JNK; pJNK; SAPK/JNK; SAPKa
Summary: Enables JUN kinase activity. Involved in several processes, including axonogenesis; defense response to other organism; and morphogenesis of an epithelium. Located in axon; dendrite; and nucleus. Is expressed in several structures, including embryonic/larval midgut primordium; epithelial furrow; head epidermis primordium; imaginal disc; and presumptive embryonic/larval system. Used to study Parkinson's disease. Human ortholog(s) of this gene implicated in several diseases, including abdominal aortic aneurysm; chronic mucocutaneous candidiasis; intestinal benign neoplasm (multiple); pancreatic adenocarcinoma; and type 2 diabetes mellitus. Orthologous to several human genes including MAPK10 (mitogen-activated protein kinase 10) and MAPK8 (mitogen-activated protein kinase 8). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 31B1-31B1; 2-40 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (10247502..10250501, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (10247502..10250501, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Gp93 inhibits unfolded protein response-mediated c-Jun N-terminal kinase activation and cell invasion.
Title: Gp93 inhibits unfolded protein response-mediated c-Jun N-terminal kinase activation and cell invasion.
N-Acetyltransferase 9 ameliorates Abeta42-mediated neurodegeneration in the Drosophila eye.
Title: N-Acetyltransferase 9 ameliorates Aβ42-mediated neurodegeneration in the Drosophila eye.
c-Jun N-Terminal Kinase Promotes Stress Granule Assembly and Neurodegeneration in C9orf72-Mediated ALS and FTD.
Title: c-Jun N-Terminal Kinase Promotes Stress Granule Assembly and Neurodegeneration in C9orf72-Mediated ALS and FTD.
Rab11 negatively regulates wingless preventing JNK-mediated apoptosis in Drosophila epithelium during embryonic dorsal closure.
Title: Rab11 negatively regulates wingless preventing JNK-mediated apoptosis in Drosophila epithelium during embryonic dorsal closure.
Bilateral JNK activation is a hallmark of interface surveillance and promotes elimination of aberrant cells.
Title: Bilateral JNK activation is a hallmark of interface surveillance and promotes elimination of aberrant cells.
Constitutive immune activity promotes JNK- and FoxO-dependent remodeling of Drosophila airways.
Title: Constitutive immune activity promotes JNK- and FoxO-dependent remodeling of Drosophila airways.
JNK Signaling in Drosophila Aging and Longevity.
Title: JNK Signaling in Drosophila Aging and Longevity.
Microenvironmental innate immune signaling and cell mechanical responses promote tumor growth.
Title: Microenvironmental innate immune signaling and cell mechanical responses promote tumor growth.
ZnT7 RNAi favors Raf(GOF)scrib(-/-)-induced tumor growth and invasion in Drosophila through JNK signaling pathway.
Title: ZnT7 RNAi favors Raf(GOF)scrib(-/-)-induced tumor growth and invasion in Drosophila through JNK signaling pathway.
Deltex positively regulates Toll signaling in a JNK independent manner in Drosophila.
Title: Deltex positively regulates Toll signaling in a JNK independent manner in Drosophila.

Submit: New GeneRIF Correction See all GeneRIFs (66)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables JUN kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables JUN kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables JUN kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables MAP kinase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in JNK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in JNK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in JNK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in antibacterial humoral response	IDA Inferred from Direct Assay more info	PubMed
involved_in axon extension	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axon guidance	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to arsenic-containing substance	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to cadmium ion	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to reactive oxygen species	IDA Inferred from Direct Assay more info	PubMed
NOT involved_in cellular response to starvation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chorion micropyle formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in collateral sprouting of injured axon	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to Gram-negative bacterium	IGI Inferred from Genetic Interaction more info	PubMed
involved_in determination of digestive tract left/right asymmetry	IGI Inferred from Genetic Interaction more info	PubMed
involved_in dorsal appendage formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dorsal closure	IGI Inferred from Genetic Interaction more info	PubMed
involved_in dorsal closure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dorsal closure, spreading of leading edge cells	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryonic anterior midgut (ectodermal) morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in engulfment of apoptotic cell	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in follicle cell of egg chamber development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc fusion, thorax closure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived male genitalia morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in long-term memory	IGI Inferred from Genetic Interaction more info	PubMed
involved_in melanization defense response	IGI Inferred from Genetic Interaction more info	PubMed
involved_in melanization defense response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mushroom body development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron projection morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peptidoglycan recognition protein signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of positive regulation of apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of positive regulation of autophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of border follicle cell migration	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of border follicle cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neuron remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of positive regulation of programmed cell death	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of cellular response to phosphate starvation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in response to heat	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tumor necrosis factor-mediated signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in vascular endothelial growth factor receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in wound healing	IDA Inferred from Direct Assay more info	PubMed
involved_in wound healing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in wound healing, spreading of epidermal cells	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in axon	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: basket

Names: CG5680-PB; CG5680-PE; CG5680-PF; JNK; JUN kinase; Jun N-terminal kinase; Jun NH2-terminal kinase; Jun-N terminal kinase; Jun-N-terminal kinase; Jun-kinase; bsk-PB; bsk-PE; bsk-PF; c-Jun N-terminal kinase; c-Jun aminoterminal kinase; c-Jun-N-terminal kinase; pJNK

NP_001162930.1

EC 2.7.11.24

NP_001162932.1

EC 2.7.11.24

NP_723541.1

EC 2.7.11.24

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

10247502..10250501 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_164900.3 → NP_723541.1 basket, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_723541.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O01366, P92208, Q94542

UniProtKB/TrEMBL

E1JHD6

Related

FBpp0079676

Conserved Domains (1) summary

cd07850
Location:23 → 359

STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
NM_001169459.1 → NP_001162930.1 basket, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001162930.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O01366, P92208, Q94542

UniProtKB/TrEMBL

E1JHD6

Conserved Domains (1) summary

cd07850
Location:23 → 359

STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
NM_001169461.3 → NP_001162932.1 basket, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001162932.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O01366, P92208, Q94542

UniProtKB/TrEMBL

E1JHD6

Conserved Domains (1) summary

cd07850
Location:23 → 359

STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase