Regnase-1 Regnase 1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Regnase-1provided by FlyBase
Official Full Name: Regnase 1provided by FlyBase
Primary source: FLYBASE:FBgn0038769
Locus tag: Dmel_CG10889
See related: AllianceGenome:FB:FBgn0038769
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG10889; Dmel\CG10889
Summary: Predicted to enable RNA endonuclease activity and mRNA binding activity. Involved in mRNA catabolic process and miRNA catabolic process. Predicted to be active in cytoplasmic ribonucleoprotein granule and nucleus. Is expressed in organism. Human ortholog(s) of this gene implicated in hepatitis B. Orthologous to several human genes including ZC3H12A (zinc finger CCCH-type containing 12A); ZC3H12B (zinc finger CCCH-type containing 12B); and ZC3H12C (zinc finger CCCH-type containing 12C). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (20033881..20036056, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (15859603..15861778, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Post-transcriptional regulation of immunological responses by Regnase-1-related RNases.
Title: Post-transcriptional regulation of immunological responses by Regnase-1-related RNases.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables RNA endonuclease activity	IBA Inferred from Biological aspect of Ancestor more info
enables RNA nuclease activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in mRNA catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in miRNA catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasmic ribonucleoprotein granule	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

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The following sections contain reference sequences that belong to a specific genome build. Explain