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    CG3225 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33680, updated on 17-Dec-2024

    Summary

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    Official Symbol
    CG3225provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0031631
    Locus tag
    Dmel_CG3225
    See related
    AllianceGenome:FB:FBgn0031631
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    cg3225; Dmel\CG3225
    Summary
    Predicted to enable RNA binding activity and helicase activity. Predicted to be involved in mRNA splicing, via spliceosome. Part of catalytic step 2 spliceosome and precatalytic spliceosome. Is expressed in organism. Orthologous to human DHX35 (DEAH-box helicase 35). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG3225 in Genome Data Viewer
    Location:
    25A6-25A7; 2-13 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (4815613..4818245, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (4815613..4818245, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene schlaff Neighboring gene long non-coding RNA:CR45297 Neighboring gene uncharacterized protein Neighboring gene mir-4910 stem loop Neighboring gene uncharacterized protein Neighboring gene mir-4912 stem loop Neighboring gene Farnesyl transferase alpha subunit

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of PSMB5 as a genetic modifier of fragile X-associated tremor/ataxia syndrome. Kong HE, et al. Proc Natl Acad Sci U S A, 2022 May 31. PMID 35617426, Free PMC Article
    2. Mextli is a novel eukaryotic translation initiation factor 4E-binding protein that promotes translation in Drosophila melanogaster. Hernández G, et al. Mol Cell Biol, 2013 Aug. PMID 23716590, Free PMC Article
    3. A small genomic region containing several loci required for gastrulation in Drosophila. Mathew SJ, et al. PLoS One, 2009 Oct 13. PMID 19823683, Free PMC Article
    4. Tracing the origin of the compensasome: evolutionary history of DEAH helicase and MYST acetyltransferase gene families. Sanjuán R, et al. Mol Biol Evol, 2001 Mar. PMID 11230534
    5. Computational and experimental identification of mirtrons in Drosophila melanogaster and Caenorhabditis elegans. Chung WJ, et al. Genome Res, 2011 Feb. PMID 21177960, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables helicase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mRNA splicing, via spliceosome IC
    Inferred by Curator
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of catalytic step 2 spliceosome HDA PubMed 
    part_of catalytic step 2 spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of precatalytic spliceosome HDA PubMed 

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG3225-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      4815613..4818245 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135016.3 → NP_608860.1  uncharacterized protein Dmel_CG3225 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608860.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T0C0, Q9VR29
      Related
      FBpp0077107
      Conserved Domains (5) summary
      smart00490
      Location:289 → 380
      HELICc; helicase superfamily c-terminal domain
      smart00847
      Location:448 → 534
      HA2; Helicase associated domain (HA2) Add an annotation
      COG1643
      Location:40 → 668
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
      cd00046
      Location:64 → 202
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      pfam07717
      Location:581 → 670
      OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VR29 Q9VR29

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