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    Cals Calsyntenin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43824, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Calsprovided by FlyBase
    Official Full Name
    Calsynteninprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039928
    Locus tag
    Dmel_CG11059
    See related
    AllianceGenome:FB:FBgn0039928
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Alcalpha; Cad102F; cals; CALS; CG11059; CT30877; dAlc; DCad102F; Dmel\CG11059
    Summary
    Predicted to enable calcium ion binding activity. Predicted to be involved in several processes, including calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; cell-cell adhesion mediated by cadherin; and positive regulation of synapse assembly. Predicted to be located in extracellular region and plasma membrane. Predicted to be active in cell surface and postsynaptic membrane. Is expressed in several structures, including adult head; follicle cell; and spermatozoon. Orthologous to several human genes including CLSTN2 (calsyntenin 2) and CLSTN3 (calsyntenin 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Cals in Genome Data Viewer
    Location:
    102F8-102F8; 4-0 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 4 NC_004353.4 (1112874..1123357, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 4 NC_004353.3 (1133500..1143983, complement)

    Chromosome 4 - NC_004353.4Genomic Context describing neighboring genes Neighboring gene apolipophorin Neighboring gene Zyxin Neighboring gene Activin-beta Neighboring gene shaven Neighboring gene uncharacterized protein Neighboring gene ADP ribosylation factor 4 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Calsyntenin-1, a proteolytically processed postsynaptic membrane protein with a cytoplasmic calcium-binding domain. Vogt L, et al. Mol Cell Neurosci, 2001 Jan. PMID 11161476
    2. Overexpression of dilp2 causes nutrient-dependent semi-lethality in Drosophila. Sato-Miyata Y, et al. Front Physiol, 2014. PMID 24795642, Free PMC Article
    3. The novel cargo Alcadein induces vesicle association of kinesin-1 motor components and activates axonal transport. Araki Y, et al. EMBO J, 2007 Mar 21. PMID 17332754, Free PMC Article
    4. Cadherins in embryonic and neural morphogenesis. Tepass U, et al. Nat Rev Mol Cell Biol, 2000 Nov. PMID 11253370
    5. Genome-wide RNAi screen of Ca(2+) influx identifies genes that regulate Ca(2+) release-activated Ca(2+) channel activity. Zhang SL, et al. Proc Natl Acad Sci U S A, 2006 Jun 13. PMID 16751269, Free PMC Article

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    mobile_element

    • Loc: c1114923-1114475 mobile_element_type = transposon:INE-1{}3451
    • Loc: c1120973-1120874 mobile_element_type = transposon:INE-1{}5501
    • Loc: c1121309-1121196 mobile_element_type = transposon:INE-1{}5499

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium ion binding ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in cell-cell adhesion mediated by cadherin ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of synapse assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in postsynaptic membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in postsynaptic membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    calsyntenin
    Names
    CG11059-PA
    CG11059-PB
    CG11059-PC
    CG11059-PD
    Cals-PA
    Cals-PB
    Cals-PC
    Cals-PD
    Calsyntenin-1
    alcadeinalpha
    calsyntenin-1-like

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004353.4 Reference assembly

      Range
      1112874..1123357 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001297793.1 → NP_001284722.1  calsyntenin, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001284722.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V137, Q9GP64, Q9V498
      UniProtKB/TrEMBL
      X2J9E8
      Conserved Domains (2) summary
      cd11304
      Location:147 → 238
      Cadherin_repeat; Cadherin tandem repeat domain
      cl22861
      Location:435 → 527
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

    2. NM_166823.2 → NP_726646.1  calsyntenin, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726646.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V137, Q9GP64, Q9V498
      UniProtKB/TrEMBL
      X2J9E8
      Related
      FBpp0088272
      Conserved Domains (2) summary
      cd11304
      Location:147 → 238
      Cadherin_repeat; Cadherin tandem repeat domain
      cl22861
      Location:435 → 527
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

    3. NM_079893.3 → NP_524632.1  calsyntenin, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524632.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V137, Q9GP64, Q9V498
      UniProtKB/TrEMBL
      X2J9E8
      Related
      FBpp0088271
      Conserved Domains (2) summary
      cd11304
      Location:147 → 238
      Cadherin_repeat; Cadherin tandem repeat domain
      cl22861
      Location:435 → 527
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

    4. NM_001272157.1 → NP_001259086.1  calsyntenin, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259086.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      L0MQ08
      Conserved Domains (2) summary
      cd11304
      Location:147 → 238
      Cadherin_repeat; Cadherin tandem repeat domain
      cl22861
      Location:435 → 527
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    L0MQ08 L0MQ08
    Q9V498.2 Q9V498
    X2J9E8 X2J9E8

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