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    MED6 Mediator complex subunit 6 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 44728, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MED6provided by FlyBase
    Official Full Name
    Mediator complex subunit 6provided by FlyBase
    Primary source
    FLYBASE:FBgn0024330
    Locus tag
    Dmel_CG9473
    See related
    AllianceGenome:FB:FBgn0024330
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-EST:Posey279; BcDNA:LD15729; CG9473; dMed6; dMED6; Dmel\CG9473; dTRAP32; med6; Med6; p35; Trap32
    Summary
    Enables transcription coregulator activity. Contributes to transcription coactivator activity. Involved in regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Part of mediator complex. Is expressed in several structures, including anterior endoderm; central brain primordium; embryonic brain; embryonic/larval midgut; and embryonic/larval midgut primordium. Orthologous to human MED6 (mediator complex subunit 6). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See MED6 in Genome Data Viewer
    Location:
    85E8-85E8; 3-49 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (9766031..9768984, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (5591753..5594706, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Mannose phosphate isomerase Neighboring gene Synaptosomal-associated protein 24kDa Neighboring gene uncharacterized protein Neighboring gene N(alpha)-acetyltransferase 80 Neighboring gene uncharacterized protein Neighboring gene WHAMM and JMY related

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Imp and Syp mediated temporal patterning of neural stem cells in the developing Drosophila CNS. Islam IM, et al. Genetics, 2022 Aug 30. PMID 35881070, Free PMC Article
    2. Imp and Syp RNA-binding proteins govern decommissioning of Drosophila neural stem cells. Yang CP, et al. Development, 2017 Oct 1. PMID 28851709, Free PMC Article
    3. Evidence for a mediator of RNA polymerase II transcriptional regulation conserved from yeast to man. Boube M, et al. Cell, 2002 Jul 26. PMID 12150923
    4. Signal-induced transcriptional activation by Dif requires the dTRAP80 mediator module. Park JM, et al. Mol Cell Biol, 2003 Feb. PMID 12556495, Free PMC Article
    5. Mediator, not holoenzyme, is directly recruited to the heat shock promoter by HSF upon heat shock. Park JM, et al. Mol Cell, 2001 Jul. PMID 11511356

    See all (51) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    contributes_to transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transcription coregulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription coregulator activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in defense response to Gram-negative bacterium HMP PubMed 
    involved_in negative regulation of innate immune response HMP PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of core mediator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of mediator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mediator complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of mediator complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of mediator complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in nucleoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    mediator complex subunit 6
    Names
    CG9473-PA
    CG9473-PB
    CG9473-PC
    CG9473-PD
    CG9473-PE
    MED6-PA
    MED6-PB
    MED6-PC
    MED6-PD
    MED6-PE
    mediator

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      9766031..9768984 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_169310.2 → NP_731403.2  mediator complex subunit 6, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731403.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MSX2, Q9VH74
      UniProtKB/TrEMBL
      E1JIH5
      Related
      FBpp0081639, FBtr0082161
      Conserved Domains (1) summary
      pfam04934
      Location:13 → 139
      Med6; MED6 mediator sub complex component

    2. NM_143731.6 → NP_651988.2  mediator complex subunit 6, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651988.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MSX2, Q9VH74
      UniProtKB/TrEMBL
      E1JIH5
      Related
      FBpp0081640
      Conserved Domains (1) summary
      pfam04934
      Location:13 → 139
      Med6; MED6 mediator sub complex component

    3. NM_001170106.1 → NP_001163577.1  mediator complex subunit 6, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163577.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MSX2, Q9VH74
      UniProtKB/TrEMBL
      E1JIH5
      Conserved Domains (1) summary
      pfam04934
      Location:13 → 139
      Med6; MED6 mediator sub complex component

    4. NM_001170107.1 → NP_001163578.1  mediator complex subunit 6, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163578.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MSX2, Q9VH74
      UniProtKB/TrEMBL
      E1JIH5
      Conserved Domains (1) summary
      pfam04934
      Location:13 → 139
      Med6; MED6 mediator sub complex component

    5. NM_001300335.1 → NP_001287264.1  mediator complex subunit 6, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287264.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MSX2, Q9VH74
      UniProtKB/TrEMBL
      E1JIH5
      Conserved Domains (1) summary
      pfam04934
      Location:13 → 139
      Med6; MED6 mediator sub complex component
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E1JIH5 E1JIH5
    Q8MSX2.1 Q8MSX2

    Gene LinkOut

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