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    Tnks tankyrase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43095, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tnksprovided by FlyBase
    Official Full Name
    tankyraseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0027508
    Locus tag
    Dmel_CG4719
    See related
    AllianceGenome:FB:FBgn0027508
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:LD22548; CG17487; CG4719; dARTD5; Dm.pARTb; Dmel\CG4719; dTANK; dTNKS; DTNKS; Tankyrase; TkrsIR; TNKS
    Summary
    Enables NAD+-protein poly-ADP-ribosyltransferase activity. Involved in positive regulation of JNK cascade; positive regulation of canonical Wnt signaling pathway; and positive regulation of proteasomal ubiquitin-dependent protein catabolic process. Located in nucleus. Is active in cytosol. Orthologous to human TNKS (tankyrase) and TNKS2 (tankyrase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Tnks in Genome Data Viewer
    Location:
    96E7-96E8; 3-88 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (25653091..25661286, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (21478813..21487008, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene jing interacting gene regulatory 1 Neighboring gene mir-92a stem loop Neighboring gene long non-coding RNA:CR45917 Neighboring gene mir-92b stem loop Neighboring gene antisense RNA:CR46101 Neighboring gene antisense RNA:CR45208 Neighboring gene Ras association domain family member 8 Neighboring gene Leucine-rich repeat-containing G protein-coupled receptor 3 Neighboring gene long non-coding RNA:CR45225

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Poly(ADP-Ribose) Prevents Pathological Phase Separation of TDP-43 by Promoting Liquid Demixing and Stress Granule Localization. McGurk L, et al. Mol Cell, 2018 Sep 6. PMID 30100264, Free PMC Article
    2. CRISPR-based engineering of gene knockout cells by homology-directed insertion in polyploid Drosophila S2R+ cells. Xia B, et al. Nat Protoc, 2020 Oct. PMID 32958931, Free PMC Article
    3. Poly(ADP-ribosyl)ation by PARP-1: 'PAR-laying' NAD+ into a nuclear signal. Kim MY, et al. Genes Dev, 2005 Sep 1. PMID 16140981
    4. In silico characterization of the family of PARP-like poly(ADP-ribosyl)transferases (pARTs). Otto H, et al. BMC Genomics, 2005 Oct 4. PMID 16202152, Free PMC Article
    5. A Context-Dependent Role for the RNF146 Ubiquitin Ligase in Wingless/Wnt Signaling in Drosophila. Wang Z, et al. Genetics, 2019 Mar. PMID 30593492, Free PMC Article

    See all (57) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the role of DTNKS in regulating apoptosis by activating JNK signaling in Drosophila.
      Title: Tankyrase regulates apoptosis by activating JNK signaling in Drosophila.
    2. These findings reveal the requirement for Tnks in the control of intestinal stem cell proliferation and suggest an essential role in the amplification of Wnt signaling, with relevance for development, homeostasis and cancer.
      Title: The ADP-ribose polymerase Tankyrase regulates adult intestinal stem cell proliferation during homeostasis in Drosophila.
    3. DTNKS regulated Wg signaling and wing patterning at a high Daxin protein level, but not at a normal level.
      Title: The Drosophila tankyrase regulates Wg signaling depending on the concentration of Daxin.
    4. Study identify the ADP-ribosyltransferase tankyrase (TNKS) and the 19S assembly chaperones dp27 and dS5b as direct binding partners of the proteasome regulator PI31.
      Title: Proteasome regulation by ADP-ribosylation.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables NAD+-protein poly-ADP-ribosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables NAD+-protein poly-ADP-ribosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables NAD+-protein poly-ADP-ribosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NAD+-protein poly-ADP-ribosyltransferase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables NAD+-protein poly-ADP-ribosyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    NOT involved_in larval chitin-based cuticle development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of JNK cascade IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of canonical Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of canonical Wnt signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of telomere capping IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to chromosome, telomeric region IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    NOT involved_in segment polarity determination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tankyrase
    Names
    CG4719-PA
    CG4719-PB
    Tnks-PA
    Tnks-PB
    dTankyrase
    NP_001262963.1
    NP_651410.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      25653091..25661286 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143153.3 → NP_651410.1  tankyrase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651410.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VBP3, Q9XZ37
      Related
      FBpp0084264
      Conserved Domains (8) summary
      cd09524
      Location:887 → 952
      SAM_tankyrase1,2; SAM domain of tankyrase1,2 subfamily
      smart00454
      Location:890 → 952
      SAM; Sterile alpha motif
      cd00204
      Location:665 → 779
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd01438
      Location:948 → 1170
      tankyrase_like; Tankyrases interact with the telomere reverse transcriptase complex (TERT). Tankyrase 1 poly-ADP-ribosylates Telomere Repeat Binding Factor 1 (TRF1) while Tankyrase 2 can poly-ADP-ribosylate itself or TRF1. The tankyrases also contain multiple ankyrin ...
      pfam00644
      Location:961 → 1165
      PARP; Poly(ADP-ribose) polymerase catalytic domain
      pfam12796
      Location:677 → 769
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:486 → 540
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:672 → 703
      ANK; ANK repeat [structural motif]

    2. NM_001276034.1 → NP_001262963.1  tankyrase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262963.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KI19
      Conserved Domains (8) summary
      cd09524
      Location:887 → 952
      SAM_tankyrase1,2; SAM domain of tankyrase1,2 subfamily
      smart00454
      Location:890 → 952
      SAM; Sterile alpha motif
      cd00204
      Location:665 → 779
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd01438
      Location:948 → 1170
      tankyrase_like; Tankyrases interact with the telomere reverse transcriptase complex (TERT). Tankyrase 1 poly-ADP-ribosylates Telomere Repeat Binding Factor 1 (TRF1) while Tankyrase 2 can poly-ADP-ribosylate itself or TRF1. The tankyrases also contain multiple ankyrin ...
      pfam00644
      Location:961 → 1165
      PARP; Poly(ADP-ribose) polymerase catalytic domain
      pfam12796
      Location:524 → 616
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:486 → 540
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:672 → 703
      ANK; ANK repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KI19 A0A0B4KI19
    Q9VBP3.1 Q9VBP3

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