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    Catsup Catecholamines up [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 48805, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Catsupprovided by FlyBase
    Official Full Name
    Catecholamines upprovided by FlyBase
    Primary source
    FLYBASE:FBgn0002022
    Locus tag
    Dmel_CG10449
    See related
    AllianceGenome:FB:FBgn0002022
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Bc; catsup; CATSUP; cg10449; CG10449; dCATSUP; Dmel\CG10449; dZIP7; dZipCatsup; dZipCATSUP; fs(2)ltoQT50; l(2)37Bc; l(2)E13; l(2)k05402; l(2)k05424; ZipCatsup
    Summary
    Enables enzyme regulator activity. Involved in detoxification of zinc ion; regulation of catecholamine metabolic process; and regulation of epithelial cell migration. Located in several cellular components, including neuronal cell body; perinuclear endoplasmic reticulum; and synaptic vesicle. Is active in endoplasmic reticulum membrane. Is expressed in several structures, including adult brain; adult head; anterior endoderm; anterior endoderm anlage; and gut section. Human ortholog(s) of this gene implicated in agammaglobulinemia 9. Orthologous to human SLC39A7 (solute carrier family 39 member 7). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Catsup in Genome Data Viewer
    Location:
    37B11-37B11; 2-54 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (19041862..19043614)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (19041862..19043614)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene hook Neighboring gene uncharacterized protein Neighboring gene mind bomb 2 Neighboring gene Tetratricopeptide repeat domain 19 Neighboring gene Acinus Neighboring gene uncharacterized protein Neighboring gene lethal (2) 37Bb

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The expression of Catsup in the hindgut is essential for zinc homeostasis in Drosophila melanogaster. Jin L, et al. Insect Mol Biol, 2024 Dec. PMID 38664880
    2. The expression of Catsup in escort cells affects Drosophila ovarian stem cell niche establishment and germline stem cells self-renewal via Notch signaling. Gao J, et al. Biochem Biophys Res Commun, 2023 Jan 22. PMID 36516479
    3. Dopamine drives Drosophila sechellia adaptation to its toxic host. Lavista-Llanos S, et al. Elife, 2014 Dec 9. PMID 25487989, Free PMC Article
    4. Phenotypic variation and natural selection at catsup, a pleiotropic quantitative trait gene in Drosophila. Carbone MA, et al. Curr Biol, 2006 May 9. PMID 16682353, Free PMC Article
    5. Disruption of dopamine homeostasis has sexually dimorphic effects on senescence characteristics of Drosophila melanogaster. Bednářová A, et al. Eur J Neurosci, 2017 Mar. PMID 28112452, Free PMC Article

    See all (102) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The expression of Catsup in the hindgut is essential for zinc homeostasis in Drosophila melanogaster.
      Title: The expression of Catsup in the hindgut is essential for zinc homeostasis in Drosophila melanogaster.
    2. Loss of Catsup function causes Notch to accumulate abnormally in the endoplasmic reticulum (ER) and Golgi compartments, resulting in impaired Notch signaling. In addition, Catsup mutant cells exhibit elevated ER stress, suggesting that impaired zinc homeostasis causes increased levels of misfolded proteins within the secretory compartment.
      Title: Protein trafficking abnormalities in Drosophila tissues with impaired activity of the ZIP7 zinc transporter Catsup.
    3. The results of this study concluded that Catsup regulates and links the dopamine synthesis and transport networks.
      Title: Catecholamines up integrates dopamine synthesis and synaptic trafficking.
    4. Molecular polymorphisms in Catsup (Catecholamines up) are associated with variation in sleep.
      Title: Co-regulated transcriptional networks contribute to natural genetic variation in Drosophila sleep.
    5. Catsup is a pleiotropic quantitative trait gene, but individual quantitative trait nucleotides do not have pleiotropic effects. Molecular population genetic analyses are consistent with balancing selection maintaining multiple functional polymorphisms.
      Title: Phenotypic variation and natural selection at catsup, a pleiotropic quantitative trait gene in Drosophila.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables enzyme regulator activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables metal ion transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion transmembrane transporter activity IC
    Inferred by Curator
    more info
    		 PubMed 
    enables zinc ion transmembrane transporter activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in detoxification of zinc ion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular zinc ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in metal ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ovarian nurse cell to oocyte transport HMP PubMed 
    involved_in positive regulation of border follicle cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of catecholamine metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of epithelial cell migration, open tracheal system IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in zinc ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in zinc ion transmembrane transport TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in axon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in perinuclear endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in synaptic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    catecholamines up
    Names
    CG10449-PA
    Catsup-PA
    catsup

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      19041862..19043614
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_080192.3 → NP_524931.1  catecholamines up [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524931.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9V3A4
      UniProtKB/TrEMBL
      Q2EJB6, Q2EJC0, Q2EJK9, Q2EJP0, Q2EJP5, Q2EJR7, Q2EJS1
      Related
      FBpp0080687
      Conserved Domains (1) summary
      pfam02535
      Location:129 → 446
      Zip; ZIP Zinc transporter
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q2EJA5 Q2EJA5
    Q2EJB1 Q2EJB1
    Q2EJB6 Q2EJB6
    Q2EJB7 Q2EJB7
    Q2EJC0 Q2EJC0
    Q2EJD1 Q2EJD1
    Q2EJD4 Q2EJD4
    Q2EJD6 Q2EJD6
    Q2EJD8 Q2EJD8
    Q2EJE1 Q2EJE1
    Q2EJE2 Q2EJE2
    Q2EJE6 Q2EJE6
    Q2EJE9 Q2EJE9
    Q2EJF2 Q2EJF2
    Q2EJF3 Q2EJF3
    Q2EJF5 Q2EJF5
    Q2EJG6 Q2EJG6
    Q2EJH2 Q2EJH2
    Q2EJI9 Q2EJI9
    Q2EJJ6 Q2EJJ6
    Q2EJJ7 Q2EJJ7
    Q2EJK8 Q2EJK8
    Q2EJK9 Q2EJK9
    Q2EJL0 Q2EJL0
    Q2EJL5 Q2EJL5
    Q2EJL9 Q2EJL9
    Q2EJM0 Q2EJM0
    Q2EJM1 Q2EJM1
    Q2EJM5 Q2EJM5
    Q2EJM6 Q2EJM6
    Q2EJN0 Q2EJN0
    Q2EJN2 Q2EJN2
    Q2EJP0 Q2EJP0
    Q2EJP2 Q2EJP2
    Q2EJP5 Q2EJP5
    Q2EJQ0 Q2EJQ0
    Q2EJQ2 Q2EJQ2
    Q2EJQ4 Q2EJQ4
    Q2EJQ6 Q2EJQ6
    Q2EJQ7 Q2EJQ7
    Q2EJQ8 Q2EJQ8
    Q2EJQ9 Q2EJQ9
    Q2EJR0 Q2EJR0
    Q2EJR1 Q2EJR1
    Q2EJR3 Q2EJR3
    Q2EJR5 Q2EJR5
    Q2EJR6 Q2EJR6
    Q2EJR7 Q2EJR7
    Q2EJS1 Q2EJS1
    Q9V3A4.1 Q9V3A4

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