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    CaBP1 calcium-binding protein 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34976, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CaBP1provided by FlyBase
    Official Full Name
    calcium-binding protein 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0025678
    Locus tag
    Dmel_CG5809
    See related
    AllianceGenome:FB:FBgn0025678
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    AAL28897; BG:DS09218.4; CaBp1; CG5809; DmCaBP1; Dmel\CG5809
    Summary
    Predicted to enable protein-disulfide reductase activity. Involved in positive regulation of apoptotic cell clearance. Located in endoplasmic reticulum. Is expressed in several structures, including adult heart; embryonic anal pad; embryonic dorsal epidermis; gut section; and head. Orthologous to human PDIA6 (protein disulfide isomerase family A member 6). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CaBP1 in Genome Data Viewer
    Location:
    35F12-35F12; 2-52 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (16354886..16356735, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (16354886..16356735, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Hyls1 centriolar and ciliogenesis associated Neighboring gene chiffon Neighboring gene uncharacterized protein Neighboring gene juvenile hormone acid methyltransferase Neighboring gene uncharacterized protein Neighboring gene Imaginal disc growth factor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A homologue of the calcium-binding disulfide isomerase CaBP1 is expressed in the developing CNS of Drosophila melanogaster. Li Y, et al. Dev Genet, 1998. PMID 9770267
    2. Apoptosis-dependent externalization and involvement in apoptotic cell clearance of DmCaBP1, an endoplasmic reticulum protein of Drosophila. Okada R, et al. J Biol Chem, 2012 Jan 27. PMID 22158613, Free PMC Article
    3. Protection of Insects against Viral Infection by Apoptosis-Dependent Phagocytosis. Nainu F, et al. J Immunol, 2015 Dec 15. PMID 26546607
    4. The Drosophila ETV5 Homologue Ets96B: Molecular Link between Obesity and Bipolar Disorder. Williams MJ, et al. PLoS Genet, 2016 Jun. PMID 27280443, Free PMC Article
    5. The thioredoxin-like fold: hidden domains in protein disulfide isomerases and other chaperone proteins. Clissold PM, et al. Bioessays, 2003 Jun. PMID 12766950

    See all (52) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Apoptosis-dependent externalization and involvement in apoptotic cell clearance of DmCaBP1, an endoplasmic reticulum protein of Drosophila.
      Title: Apoptosis-dependent externalization and involvement in apoptotic cell clearance of DmCaBP1, an endoplasmic reticulum protein of Drosophila.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein disulfide isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-disulfide reductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of apoptotic cell clearance IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of apoptotic cell clearance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to endoplasmic reticulum stress IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in endomembrane system HDA PubMed 
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    calcium-binding protein 1
    Names
    CG5809-PA
    CG5809-PB
    CaBP1-PA
    CaBP1-PB
    NP_001285979.1
    NP_609792.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      16354886..16356735 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299050.1 → NP_001285979.1  calcium-binding protein 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285979.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9V438
      Conserved Domains (3) summary
      cd02983
      Location:271 → 400
      P5_C; P5 family, C-terminal redox inactive TRX-like domain; P5 is a protein disulfide isomerase (PDI)-related protein with a domain structure of aa'b (where a and a' are redox active TRX domains and b is a redox inactive TRX-like domain). Like PDI, P5 is ...
      cd03001
      Location:157 → 262
      PDI_a_P5; PDIa family, P5 subfamily; composed of eukaryotic proteins similar to human P5, a PDI-related protein with a domain structure of aa'b (where a and a' are redox active TRX domains and b is a redox inactive TRX-like domain). Like PDI, P5 is located in the ...
      pfam13848
      Location:190 → 383
      Thioredoxin_6; Thioredoxin-like domain

    2. NM_135948.4 → NP_609792.1  calcium-binding protein 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609792.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9V438
      Related
      FBpp0080395
      Conserved Domains (3) summary
      cd02983
      Location:271 → 400
      P5_C; P5 family, C-terminal redox inactive TRX-like domain; P5 is a protein disulfide isomerase (PDI)-related protein with a domain structure of aa'b (where a and a' are redox active TRX domains and b is a redox inactive TRX-like domain). Like PDI, P5 is ...
      cd03001
      Location:157 → 262
      PDI_a_P5; PDIa family, P5 subfamily; composed of eukaryotic proteins similar to human P5, a PDI-related protein with a domain structure of aa'b (where a and a' are redox active TRX domains and b is a redox inactive TRX-like domain). Like PDI, P5 is located in the ...
      pfam13848
      Location:190 → 383
      Thioredoxin_6; Thioredoxin-like domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9V438.1 Q9V438

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