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    Isha Insulator su(Hw) mRNA adaptor [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37411, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ishaprovided by FlyBase
    Official Full Name
    Insulator su(Hw) mRNA adaptorprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034598
    Locus tag
    Dmel_CG4266
    See related
    AllianceGenome:FB:FBgn0034598
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    cg4266; CG4266; Dmel\CG4266
    Summary
    Enables chromatin binding activity and mRNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Located in chromatin. Is expressed in larval ventral nerve cord and organism. Orthologous to human SCAF4 (SR-related CTD associated factor 4) and SCAF8 (SR-related CTD associated factor 8). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    NEW
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    Genomic context

    See Isha in Genome Data Viewer
    Location:
    57C6-57C7; 2-93 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (21161713..21168659, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (17049218..17056164, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene transfer RNA:Glycine-GCC 1-12 Neighboring gene transfer RNA:Tryptophan-CCA 2-4 Neighboring gene hinge1 Neighboring gene Like Sm 1 Neighboring gene Xeroderma pigmentosum D

    Genomic regions, transcripts, and products

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables mRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    insulator su(Hw) mRNA adaptor
    Names
    CG4266-PA
    CG4266-PB
    CG4266-PC
    CG4266-PD
    Isha-PA
    Isha-PB
    Isha-PC
    Isha-PD

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      21161713..21168659 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299735.1NP_001286664.1  insulator su(Hw) mRNA adaptor, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286664.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LH25
      Conserved Domains (5) summary
      COG0724
      Location:394499
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd03562
      Location:7125
      CID; CID (CTD-Interacting Domain) domain family; CID is present in several RNA-processing factors such as Pcf11 and Nrd1. Pcf11 is a conserved and essential subunit of the yeast cleavage factor IA, which is required for polyadenylation-dependent 3'-RNA ...
      cd12227
      Location:396472
      RRM_SCAF4_SCAF8; RNA recognition motif in SR-related and CTD-associated factor 4 (SCAF4), SR-related and CTD-associated factor 8 (SCAF8) and similar proteins
      pfam04929
      Location:11121210
      Herpes_DNAp_acc; Herpes DNA replication accessory factor
      pfam10310
      Location:10531160
      DUF2413; Protein of unknown function (DUF2413)
    2. NM_137713.3NP_611557.2  insulator su(Hw) mRNA adaptor, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611557.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W2K4
      Related
      FBpp0071554
      Conserved Domains (5) summary
      COG0724
      Location:397502
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd03562
      Location:7125
      CID; CID (CTD-Interacting Domain) domain family; CID is present in several RNA-processing factors such as Pcf11 and Nrd1. Pcf11 is a conserved and essential subunit of the yeast cleavage factor IA, which is required for polyadenylation-dependent 3'-RNA ...
      cd12227
      Location:399475
      RRM_SCAF4_SCAF8; RNA recognition motif in SR-related and CTD-associated factor 4 (SCAF4), SR-related and CTD-associated factor 8 (SCAF8) and similar proteins
      pfam04929
      Location:11151213
      Herpes_DNAp_acc; Herpes DNA replication accessory factor
      pfam10310
      Location:10561163
      DUF2413; Protein of unknown function (DUF2413)
    3. NM_001274190.2NP_001261119.1  insulator su(Hw) mRNA adaptor, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261119.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A2VEJ9
      Conserved Domains (1) summary
      cd03562
      Location:7125
      CID; CID (CTD-Interacting Domain) domain family; CID is present in several RNA-processing factors such as Pcf11 and Nrd1. Pcf11 is a conserved and essential subunit of the yeast cleavage factor IA, which is required for polyadenylation-dependent 3'-RNA ...
    4. NM_001103924.2NP_001097394.1  insulator su(Hw) mRNA adaptor, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097394.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8DYK5
      Conserved Domains (5) summary
      COG0724
      Location:488593
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd03562
      Location:7125
      CID; CID (CTD-Interacting Domain) domain family; CID is present in several RNA-processing factors such as Pcf11 and Nrd1. Pcf11 is a conserved and essential subunit of the yeast cleavage factor IA, which is required for polyadenylation-dependent 3'-RNA ...
      cd12227
      Location:490566
      RRM_SCAF4_SCAF8; RNA recognition motif in SR-related and CTD-associated factor 4 (SCAF4), SR-related and CTD-associated factor 8 (SCAF8) and similar proteins
      pfam04929
      Location:12061304
      Herpes_DNAp_acc; Herpes DNA replication accessory factor
      pfam10310
      Location:11471254
      DUF2413; Protein of unknown function (DUF2413)