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    CG7546 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38844, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG7546provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0035793
    Locus tag
    Dmel_CG7546
    See related
    AllianceGenome:FB:FBgn0035793
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-EST:Liang-2.45; clone 2.45; Dmel\CG7546
    Summary
    Enables enzyme binding activity. Predicted to be involved in ERAD pathway and negative regulation of apoptotic process. Predicted to be located in cytosol. Predicted to be part of BAT3 complex. Is expressed in adult head and organism. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma and osteoarthritis. Orthologous to human BAG6 (BAG cochaperone 6). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG7546 in Genome Data Viewer
    Location:
    66A3-66A3; 3-21 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (7510986..7517316)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (7504086..7510416)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45896 Neighboring gene larval translucida Neighboring gene liquid facets Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Enrichment of O-GlcNAc modified proteins by the periodate oxidation-hydrazide resin capture approach. Klement E, et al. J Proteome Res, 2010 May 7. PMID 20146544, Free PMC Article
    2. Iruka Eliminates Dysfunctional Argonaute by Selective Ubiquitination of Its Empty State. Kobayashi H, et al. Mol Cell, 2019 Jan 3. PMID 30503771
    3. Abundant conserved microRNA target sites in the 5'-untranslated region and coding sequence. Zhou X, et al. Genetica, 2009 Nov. PMID 19578934
    4. Cell death regulation in Drosophila: conservation of mechanism and unique insights. Vernooy SY, et al. J Cell Biol, 2000 Jul 24. PMID 10908589, Free PMC Article
    5. Molecular mechanisms of cell death and phagocytosis in Drosophila. Bangs P, et al. Cell Death Differ, 2000 Nov. PMID 11139274

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables misfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables polyubiquitin modification-dependent protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables polyubiquitin modification-dependent protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of BAT3 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG7546-PA
    CG7546-PB
    CG7546-PC
    CG7546-PD
    CG7546-PE
    CG7546-PF
    CG7546-PG
    CG7546-PH

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      7510986..7517316
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001274594.1 → NP_001261523.1  uncharacterized protein Dmel_CG7546, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261523.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B3DNM3, M9PEE7
      Conserved Domains (3) summary
      cd01809
      Location:3 → 73
      Scythe_N; Ubiquitin-like domain of Scythe protein
      smart00213
      Location:3 → 73
      UBQ; Ubiquitin homologues
      pfam12057
      Location:351 → 467
      DUF3538; Domain of unknown function (DUF3538)

    2. NM_001274592.1 → NP_001261521.1  uncharacterized protein Dmel_CG7546, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261521.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B3DNM3, M9PHN9
      Conserved Domains (3) summary
      cd01809
      Location:3 → 73
      Scythe_N; Ubiquitin-like domain of Scythe protein
      smart00213
      Location:3 → 73
      UBQ; Ubiquitin homologues
      pfam12057
      Location:351 → 467
      DUF3538; Domain of unknown function (DUF3538)

    3. NM_001144432.3 → NP_001137904.1  uncharacterized protein Dmel_CG7546, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137904.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B3DNM3, B7Z0D3
      Conserved Domains (3) summary
      cd01809
      Location:3 → 73
      Scythe_N; Ubiquitin-like domain of Scythe protein
      smart00213
      Location:3 → 73
      UBQ; Ubiquitin homologues
      pfam12057
      Location:350 → 466
      DUF3538; Domain of unknown function (DUF3538)

    4. NM_139875.5 → NP_648132.2  uncharacterized protein Dmel_CG7546, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648132.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      B3DNM3, Q9VS82
      Related
      FBpp0076505
      Conserved Domains (3) summary
      cd01809
      Location:3 → 73
      Scythe_N; Ubiquitin-like domain of Scythe protein
      smart00213
      Location:3 → 73
      UBQ; Ubiquitin homologues
      pfam12057
      Location:350 → 466
      DUF3538; Domain of unknown function (DUF3538)

    5. NM_001144431.3 → NP_001137903.1  uncharacterized protein Dmel_CG7546, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137903.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B3DNM3, B7Z0D4
      Conserved Domains (3) summary
      cd01809
      Location:3 → 73
      Scythe_N; Ubiquitin-like domain of Scythe protein
      smart00213
      Location:3 → 73
      UBQ; Ubiquitin homologues
      pfam12057
      Location:350 → 466
      DUF3538; Domain of unknown function (DUF3538)

    6. NM_001259730.2 → NP_001246659.1  uncharacterized protein Dmel_CG7546, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246659.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B3DNM3, M9ND57
      Conserved Domains (3) summary
      cd01809
      Location:3 → 73
      Scythe_N; Ubiquitin-like domain of Scythe protein
      smart00213
      Location:3 → 73
      UBQ; Ubiquitin homologues
      pfam12057
      Location:350 → 466
      DUF3538; Domain of unknown function (DUF3538)

    7. NM_001274593.1 → NP_001261522.1  uncharacterized protein Dmel_CG7546, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261522.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B3DNM3, M9PBU3
      Conserved Domains (3) summary
      cd01809
      Location:3 → 73
      Scythe_N; Ubiquitin-like domain of Scythe protein
      smart00213
      Location:3 → 73
      UBQ; Ubiquitin homologues
      pfam12057
      Location:350 → 466
      DUF3538; Domain of unknown function (DUF3538)

    8. NM_168217.4 → NP_729264.2  uncharacterized protein Dmel_CG7546, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729264.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      B3DNM3, Q95TP8, Q9VS83
      Related
      FBpp0076506
      Conserved Domains (3) summary
      cd01809
      Location:3 → 73
      Scythe_N; Ubiquitin-like domain of Scythe protein
      smart00213
      Location:3 → 73
      UBQ; Ubiquitin homologues
      pfam12057
      Location:350 → 466
      DUF3538; Domain of unknown function (DUF3538)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B7Z0D3 B7Z0D3
    B7Z0D4 B7Z0D4
    M9ND57 M9ND57
    M9PBU3 M9PBU3
    M9PEE7 M9PEE7
    M9PHN9 M9PHN9
    Q7K3F6 Q7K3F6
    Q8MQJ3 Q8MQJ3
    Q9VS82 Q9VS82
    Q9VS83 Q9VS83

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