CHMP2B Charged multivesicular body protein 2b [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: CHMP2Bprovided by FlyBase
Official Full Name: Charged multivesicular body protein 2bprovided by FlyBase
Primary source: FLYBASE:FBgn0035589
Locus tag: Dmel_CG4618
See related: AllianceGenome:FB:FBgn0035589
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: cg4618; CG4618; Dmel\CG4618
Summary: Predicted to be involved in endosome transport via multivesicular body sorting pathway; late endosome to vacuole transport; and protein transport. Predicted to be part of ESCRT III complex. Predicted to be active in multivesicular body. Is expressed in organism. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis; frontotemporal dementia; and frontotemporal dementia and/or amyotrophic lateral sclerosis 7. Orthologous to human CHMP2B (charged multivesicular body protein 2B). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 64C7-64C7; 3-13 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (5139619..5140473)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (5132719..5133573)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CHMP2B regulates TDP-43 phosphorylation and cytotoxicity independent of autophagy via CK1.
Title: CHMP2B regulates TDP-43 phosphorylation and cytotoxicity independent of autophagy via CK1.
Retrovirus reactivation in CHMP2BIntron5 models of frontotemporal dementia.
Title: Retrovirus reactivation in CHMP2BIntron5 models of frontotemporal dementia.
Ik2/TBK1 and Hook/Dynein, an adaptor complex for early endosome transport, are genetic modifiers of FTD-associated mutant CHMP2B toxicity in Drosophila.
Title: Ik2/TBK1 and Hook/Dynein, an adaptor complex for early endosome transport, are genetic modifiers of FTD-associated mutant CHMP2B toxicity in Drosophila.
The pro-apoptotic JNK scaffold protein POSH mediates CHMP2BIntron5-associated toxicity in animal models of frontotemporal dementia.
Title: The pro-apoptotic JNK scaffold POSH/SH3RF1 mediates CHMP2BIntron5-associated toxicity in animal models of frontotemporal dementia.
The results demonstrate that CHMP2B(Intron5) preferentially affects different receptor signaling pathways in a cellular and developmental context-dependent manner.
Title: Expression of mutant CHMP2B, an ESCRT-III component involved in frontotemporal dementia, causes eye deformities due to Notch misregulation in Drosophila.
Data show that syntaxin 13 (syx13) is a geneti modifier of the mutant CHMP2B (CHMP2BIntron5) eye phenotype.
Title: Syntaxin 13, a genetic modifier of mutant CHMP2B in frontotemporal dementia, is required for autophagosome maturation.
Spn5 is a regulator of the Toll pathway and CHMP2B (CG4618) toxicity and the Toll pathway is a major signaling pathway misregulated by mutant CHMP2B in vivo.
Title: Genetic screen identifies serpin5 as a regulator of the toll pathway and CHMP2B toxicity associated with frontotemporal dementia.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in endosomal transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in endosome transport via multivesicular body sorting pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in late endosome to vacuole transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in vacuolar transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of ESCRT III complex	IBA Inferred from Biological aspect of Ancestor more info
part_of ESCRT III complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed
is_active_in multivesicular body	IBA Inferred from Biological aspect of Ancestor more info