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    APC7 Anaphase Promoting Complex subunit 7 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31594, updated on 9-Dec-2024

    Summary

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    Official Symbol
    APC7provided by FlyBase
    Official Full Name
    Anaphase Promoting Complex subunit 7provided by FlyBase
    Primary source
    FLYBASE:FBgn0029879
    Locus tag
    Dmel_CG14444
    See related
    AllianceGenome:FB:FBgn0029879
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Apc7; CG14444; Dmel\CG14444
    Summary
    Involved in positive regulation of mitotic metaphase/anaphase transition. Part of anaphase-promoting complex. Is expressed in organism. Orthologous to human ANAPC7 (anaphase promoting complex subunit 7). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See APC7 in Genome Data Viewer
    Location:
    6C1-6C1; 1-18 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (6597088..6599699)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (6491121..6493732)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR43832 Neighboring gene uncharacterized protein Neighboring gene Protein interacting with APP tail-1 Neighboring gene pickled eggs Neighboring gene long non-coding RNA:CR44817 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome-wide association studies reveal a simple genetic basis of resistance to naturally coevolving viruses in Drosophila melanogaster. Magwire MM, et al. PLoS Genet, 2012. PMID 23166512, Free PMC Article
    2. Structurally related TPR subunits contribute differently to the function of the anaphase-promoting complex in Drosophila melanogaster. Pál M, et al. J Cell Sci, 2007 Sep 15. PMID 17878237
    3. The cytolinker Pigs is a direct target and a negative regulator of Notch signalling. Pines MK, et al. Development, 2010 Mar. PMID 20150280, Free PMC Article
    4. Deletion of Siah-interacting protein gene in Drosophila causes cardiomyopathy. Casad ME, et al. Mol Genet Genomics, 2012 Apr. PMID 22398840, Free PMC Article
    5. The anaphase-promoting complex: it's not just for mitosis any more. Harper JW, et al. Genes Dev, 2002 Sep 1. PMID 12208841

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in cell division IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of mitotic metaphase/anaphase transition IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of mitotic metaphase/anaphase transition IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of anaphase-promoting complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of anaphase-promoting complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    anaphase promoting complex subunit 7
    Names
    APC7-PA
    APC7-PB
    CG14444-PA
    CG14444-PB
    anaphase promoting complex 7

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      6597088..6599699
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132101.4 → NP_572329.3  anaphase promoting complex subunit 7, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572329.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T020, Q9W3Y6
      Related
      FBpp0070907
      Conserved Domains (2) summary
      sd00006
      Location:321 → 349
      TPR; TPR repeat [structural motif]
      pfam13414
      Location:321 → 386
      TPR_11; TPR repeat

    2. NM_167079.2 → NP_727101.1  anaphase promoting complex subunit 7, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727101.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IRQ6, Q8T020
      Related
      FBpp0070908
      Conserved Domains (4) summary
      COG0457
      Location:177 → 438
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00008
      Location:199 → 227
      TPR_YbbN; TPR repeat [structural motif]
      sd00006
      Location:234 → 262
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:406 → 438
      TPR_1; Tetratricopeptide repeat
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IRQ6 Q8IRQ6
    Q8T020 Q8T020
    Q9W3Y6 Q9W3Y6

    Gene LinkOut

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