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    Papst2 PAPS transporter 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39914, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Papst2provided by FlyBase
    Official Full Name
    PAPS transporter 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0036695
    Locus tag
    Dmel_CG7853
    See related
    AllianceGenome:FB:FBgn0036695
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG7853; Dmel\CG7853; dPAPST2; PAPST2
    Summary
    Enables 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity. Involved in 3'-phosphoadenosine 5'-phosphosulfate transport and heparan sulfate proteoglycan biosynthetic process. Located in Golgi cis cisterna and endoplasmic reticulum. Is expressed in adult head. Orthologous to human SLC35B3 (solute carrier family 35 member B3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Papst2 in Genome Data Viewer
    Location:
    73E5-73E5; 3-45 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (17042797..17044465)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (17035897..17037565)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR43250 Neighboring gene bad egg Neighboring gene SR-related CTD associated factor 6 Neighboring gene POP5 ribonuclease P/MRP subunit Neighboring gene Troponin C at 73F Neighboring gene rogdi

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Glycosyltransferases and transporters that contribute to proteoglycan synthesis in Drosophila: Identification and functional analyses using the heritable and inducible RNAi system. Nishihara S. Methods Enzymol, 2010. PMID 20816216
    2. Identification and characterization of a novel Drosophila 3'-phosphoadenosine 5'-phosphosulfate transporter. Goda E, et al. J Biol Chem, 2006 Sep 29. PMID 16873373
    3. Cisterna-specific localization of glycosylation-related proteins to the Golgi apparatus. Yamamoto-Hino M, et al. Cell Struct Funct, 2012. PMID 22251795
    4. ER membrane protein complex is required for the insertions of late-synthesized transmembrane helices of Rh1 in Drosophila photoreceptors. Hiramatsu N, et al. Mol Biol Cell, 2019 Nov 1. PMID 31553680, Free PMC Article
    5. Phenotype-based clustering of glycosylation-related genes by RNAi-mediated gene silencing. Yamamoto-Hino M, et al. Genes Cells, 2015 Jun. PMID 25940448, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. dPAPST2 may be involved in Hedgehog and Decapentaplegic signaling by controlling the sulfation of heparan sulfate
      Title: Identification and characterization of a novel Drosophila 3'-phosphoadenosine 5'-phosphosulfate transporter.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in 3'-phosphoadenosine 5'-phosphosulfate transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in 3'-phosphoadenosine 5'-phosphosulfate transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in heparan sulfate proteoglycan biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi cis cisterna IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    PAPS transporter 2
    Names
    CG7853-PA
    Papst2-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      17042797..17044465
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140697.4 → NP_648954.1  PAPS transporter 2 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648954.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0PCZ5, Q8T012, Q9VVD9
      Related
      FBpp0075039
      Conserved Domains (2) summary
      pfam00892
      Location:219 → 362
      EamA; EamA-like transporter family
      pfam08449
      Location:61 → 364
      UAA; UAA transporter family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VVD9.2 Q9VVD9

    Gene LinkOut

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