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    ics icarus [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34774, updated on 9-Dec-2024

    Summary

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    Official Symbol
    icsprovided by FlyBase
    Official Full Name
    icarusprovided by FlyBase
    Primary source
    FLYBASE:FBgn0028546
    Locus tag
    Dmel_CG9031
    See related
    AllianceGenome:FB:FBgn0028546
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BG:BACR48E02.4; CG9031; CT25926; Dmel\CG9031; Ics; Rsu-1; RSU-1; Rsu1; RSU1
    Summary
    Involved in apposition of dorsal and ventral imaginal disc-derived wing surfaces; integrin-mediated signaling pathway; and negative regulation of JNK cascade. Is expressed in adult head; adult heart; larval muscle system; larval somatic muscle cell; and organism. Used to study alcohol dependence. Orthologous to human RSU1 (Ras suppressor protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ics in Genome Data Viewer
    Location:
    34C6-34C6; 2-48 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (13639447..13642602, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (13639447..13642602, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene kuzbanian Neighboring gene mir-2489 stem loop Neighboring gene long non-coding RNA:CR43410 Neighboring gene long non-coding RNA:CR44726 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Stage-Based Model of Addiction-Using Drosophila to Investigate Alcohol and Psychostimulant Responses. Cummins-Beebee PN, et al. Int J Mol Sci, 2023 Jun 30. PMID 37446084, Free PMC Article
    2. Altered Actin Filament Dynamics in the Drosophila Mushroom Bodies Lead to Fast Acquisition of Alcohol Consumption Preference. Butts AR, et al. J Neurosci, 2019 Nov 6. PMID 31558618, Free PMC Article
    3. I Believe I Can Fly!: Use of Drosophila as a Model Organism in Neuropsychopharmacology Research. Narayanan AS, et al. Neuropsychopharmacology, 2016 May. PMID 26576740, Free PMC Article
    4. A crucial role for Ras suppressor-1 (RSU-1) revealed when PINCH and ILK binding is disrupted. Elias MC, et al. J Cell Sci, 2012 Jul 1. PMID 22467865, Free PMC Article
    5. A central multifunctional role of integrin-linked kinase at muscle attachment sites. Zervas CG, et al. J Cell Sci, 2011 Apr 15. PMID 21444757, Free PMC Article

    See all (56) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in apposition of dorsal and ventral imaginal disc-derived wing surfaces IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in integrin-mediated signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of JNK cascade IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    icarus
    Names
    CG9031-PA
    CG9031-PB
    CG9031-PC
    Ras suppressor-1
    ics-PA
    ics-PB
    ics-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      13639447..13642602 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298974.1 → NP_001285903.1  icarus, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285903.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JVW9, Q9V428
      Conserved Domains (3) summary
      COG4886
      Location:119 → 222
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:29 → 51
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:96 → 156
      LRR_8; Leucine rich repeat

    2. NM_135821.5 → NP_609665.2  icarus, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609665.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JVW9, Q9V428
      Related
      FBpp0080089
      Conserved Domains (3) summary
      COG4886
      Location:119 → 222
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:29 → 51
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:96 → 156
      LRR_8; Leucine rich repeat

    3. NM_001298973.1 → NP_001285902.1  icarus, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285902.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JVW9, Q9V428
      Conserved Domains (3) summary
      COG4886
      Location:119 → 222
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:29 → 51
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:96 → 156
      LRR_8; Leucine rich repeat
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7JVW9 Q7JVW9
    Q9V428 Q9V428

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