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    RNF220 ring finger protein 220 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42690, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RNF220provided by FlyBase
    Official Full Name
    ring finger protein 220provided by FlyBase
    Primary source
    FLYBASE:FBgn0039013
    Locus tag
    Dmel_CG4813
    See related
    AllianceGenome:FB:FBgn0039013
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4813; Dmel\CG4813
    Summary
    Predicted to enable ubiquitin protein ligase activity and zinc ion binding activity. Predicted to be involved in protein ubiquitination. Predicted to be located in cytoplasm. Is expressed in organism. Used to study hypomyelinating leukodystrophy 23. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 23. Orthologous to human RNF220 (ring finger protein 220). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See RNF220 in Genome Data Viewer
    Location:
    94C3-94C4; 3-76 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (22724884..22726414, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (18550606..18552136, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene winged eye Neighboring gene Iron regulatory protein 1A Neighboring gene antisense RNA:CR45648 Neighboring gene uncharacterized protein Neighboring gene Tak1-like 2 Neighboring gene Dicer-1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The RNF220 domain nuclear factor Teyrha-Meyrha (Tey) regulates the migration and differentiation of specific visceral and somatic muscles in Drosophila. Frasch M, et al. Development, 2023 Sep 15. PMID 37642089, Free PMC Article
    2. Biallelic mutations in RNF220 cause laminopathies featuring leukodystrophy, ataxia and deafness. Sferra A, et al. Brain, 2021 Nov 29. PMID 33964137
    3. Negative genetic correlation between longevity and its hormetic extension by dietary restriction in Drosophila melanogaster. Gomez FH, et al. Biogerontology, 2020 Apr. PMID 31786681
    4. Comprehensively surveying structure and function of RING domains from Drosophila melanogaster. Ying M, et al. PLoS One, 2011. PMID 21912646, Free PMC Article
    5. Genes conserved in bilaterians but jointly lost with Myc during nematode evolution are enriched in cell proliferation and cell migration functions. Erives AJ. Dev Genes Evol, 2015 Sep. PMID 26173873, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ubiquitin-protein transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    ring finger protein 220
    Names
    CG4813-PA
    RNF220-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      22724884..22726414 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142831.4 → NP_651088.1  ring finger protein 220 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651088.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VCV3
      Related
      FBpp0083719
      Conserved Domains (2) summary
      pfam13923
      Location:346 → 384
      zf-C3HC4_2; Zinc finger, C3HC4 type (RING finger)
      pfam15926
      Location:22 → 281
      RNF220; E3 ubiquitin-protein ligase RNF220
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VCV3 Q9VCV3

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