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    Coq3 Coenzyme Q3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35383, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Coq3provided by FlyBase
    Official Full Name
    Coenzyme Q3provided by FlyBase
    Primary source
    FLYBASE:FBgn0032922
    Locus tag
    Dmel_CG9249
    See related
    AllianceGenome:FB:FBgn0032922
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9249; Dmel\CG9249
    Summary
    Predicted to enable 3-demethylubiquinol-n 3-O-methyltransferase activity. Involved in wound healing. Predicted to be located in mitochondrial inner membrane. Predicted to be part of ubiquinone biosynthesis complex. Predicted to be active in mitochondrion. Is expressed in adult head; adult heart; embryonic/larval midgut; and organism. Orthologous to human COQ3 (coenzyme Q3, methyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Coq3 in Genome Data Viewer
    Location:
    39A6-39A6; 2-54 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (21157433..21158611, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (21157433..21158611, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene porthos Neighboring gene deadlock Neighboring gene E2F transcription factor 2 Neighboring gene M-phase phosphoprotein 6 Neighboring gene Phospholipase D family member 3 Neighboring gene Nibbler Neighboring gene antisense RNA:CR44910 Neighboring gene Nucleolar complex protein 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A Personalized Model of COQ2 Nephropathy Rescued by the Wild-Type COQ2 Allele or Dietary Coenzyme Q(10) Supplementation. Zhu JY, et al. J Am Soc Nephrol, 2017 Sep. PMID 28428331, Free PMC Article
    2. Invertebrate models for coenzyme q10 deficiency. Fernández-Ayala DJ, et al. Mol Syndromol, 2014 Jul. PMID 25126050, Free PMC Article
    3. Drosophila E2f2 promotes the conversion from genomic DNA replication to gene amplification in ovarian follicle cells. Cayirlioglu P, et al. Development, 2001 Dec. PMID 11748144
    4. In vivo screening reveals interactions between Drosophila Manf and genes involved in the mitochondria and the ubiquinone synthesis pathway. Lindström R, et al. BMC Genet, 2017 Jun 2. PMID 28578657, Free PMC Article
    5. Genetic screen in Drosophila melanogaster uncovers a novel set of genes required for embryonic epithelial repair. Campos I, et al. Genetics, 2010 Jan. PMID 19884309, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 3,4-dihydroxy-5-polyprenylbenzoic acid O-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3,4-dihydroxy-5-polyprenylbenzoic acid O-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 3-demethylubiquinol-n 3-O-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 3-demethylubiquinol-n 3-O-methyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in ubiquinone biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquinone biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in wound healing HMP PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ubiquinone biosynthesis complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    coenzyme Q3
    Names
    CG9249-PA
    CG9249-PB
    Coq3-PA
    Coq3-PB
    NP_001163029.1
    NP_610092.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      21157433..21158611 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136248.4 → NP_610092.2  coenzyme Q3, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610092.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q5BIB9, Q9VIF3
      Related
      FBpp0081028
      Conserved Domains (2) summary
      TIGR01983
      Location:41 → 297
      UbiG; ubiquinone biosynthesis O-methyltransferase
      pfam08241
      Location:100 → 200
      Methyltransf_11; Methyltransferase domain

    2. NM_001169558.2 → NP_001163029.1  coenzyme Q3, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163029.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JHN2, Q5BIB9
      Conserved Domains (2) summary
      TIGR01983
      Location:41 → 276
      UbiG; ubiquinone biosynthesis O-methyltransferase
      pfam08241
      Location:100 → 200
      Methyltransf_11; Methyltransferase domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E1JHN2 E1JHN2
    Q5BIB9 Q5BIB9
    Q95R84 Q95R84
    Q9VIF3 Q9VIF3

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