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    PIG-L Phosphatidylinositol glycan anchor biosynthesis class L [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42388, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PIG-Lprovided by FlyBase
    Official Full Name
    Phosphatidylinositol glycan anchor biosynthesis class Lprovided by FlyBase
    Primary source
    FLYBASE:FBgn0038763
    Locus tag
    Dmel_CG4433
    See related
    AllianceGenome:FB:FBgn0038763
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4433; Dmel\CG4433; PIGL
    Summary
    Predicted to enable N-acetylglucosaminylphosphatidylinositol deacetylase activity. Predicted to be involved in GPI anchor biosynthetic process. Predicted to be active in endoplasmic reticulum. Is expressed in adult head. Human ortholog(s) of this gene implicated in CHIME syndrome. Orthologous to human PIGL (phosphatidylinositol glycan anchor biosynthesis class L). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See PIG-L in Genome Data Viewer
    Location:
    92C1-92C1; 3-67 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (20018269..20021338, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (15843991..15847060, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene phagocyte signaling impaired Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Variant-to-gene mapping followed by cross-species genetic screening identifies GPI-anchor biosynthesis as a regulator of sleep. Palermo J, et al. Sci Adv, 2023 Jan 6. PMID 36608130, Free PMC Article
    2. GPI biosynthesis is essential for rhodopsin sorting at the trans-Golgi network in Drosophila photoreceptors. Satoh T, et al. Development, 2013 Jan 15. PMID 23250212
    3. Genome-wide phenotypic RNAi screen in the Drosophila wing: phenotypic description of functional classes. López-Varea A, et al. G3 (Bethesda), 2021 Dec 8. PMID 34599810, Free PMC Article
    4. CRISPR-based modular assembly of a UAS-cDNA/ORF plasmid library for more than 5500 Drosophila genes conserved in humans. Wei P, et al. Genome Res, 2020 Jan. PMID 31722958, Free PMC Article
    5. Phylostratigraphic bias creates spurious patterns of genome evolution. Moyers BA, et al. Mol Biol Evol, 2015 Jan. PMID 25312911, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables N-acetylglucosaminylphosphatidylinositol deacetylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables N-acetylglucosaminylphosphatidylinositol deacetylase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in GPI anchor biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    phosphatidylinositol glycan anchor biosynthesis class L
    Names
    CG4433-PB
    CG4433-PC
    CG4433-PD
    PIG-L-PB
    PIG-L-PC
    PIG-L-PD
    NP_001247201.1
    NP_650857.3
    NP_996241.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      20018269..20021338 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142600.3 → NP_650857.3  phosphatidylinositol glycan anchor biosynthesis class L, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650857.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KSB6, Q8MSG5, Q9VDQ8
      Conserved Domains (1) summary
      pfam02585
      Location:144 → 265
      PIG-L; GlcNAc-PI de-N-acetylase

    2. NM_001260272.2 → NP_001247201.1  phosphatidylinositol glycan anchor biosynthesis class L, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247201.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K6Q5, Q8MSG5
      Conserved Domains (1) summary
      pfam02585
      Location:144 → 265
      PIG-L; GlcNAc-PI de-N-acetylase

    3. NM_206519.2 → NP_996241.1  phosphatidylinositol glycan anchor biosynthesis class L, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996241.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KSB6, Q8MSG5, Q9VDQ8
      Conserved Domains (1) summary
      pfam02585
      Location:144 → 265
      PIG-L; GlcNAc-PI de-N-acetylase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4K6Q5 A0A0B4K6Q5
    Q7KSB6 Q7KSB6
    Q8MSG5 Q8MSG5

    Gene LinkOut

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