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    Bicra BRD4 interacting chromatin remodeling complex associated protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43435, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Bicraprovided by FlyBase
    Official Full Name
    BRD4 interacting chromatin remodeling complex associated proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039633
    Locus tag
    Dmel_CG11873
    See related
    AllianceGenome:FB:FBgn0039633
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0140519.162; CG11873; Dmel\CG11873
    Summary
    Involved in chromatin remodeling. Part of brahma complex. Is expressed in lobula; lobula plate; medulla; transmedullary Y neuron TmY27; and transmedullary neuron Tm27. Used to study Coffin-Siris syndrome. Orthologous to human BICRAL (BICRA like chromatin remodeling complex associated protein). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Bicra in Genome Data Viewer
    Location:
    98F6-98F10; 3-97 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (29063040..29108948)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (24888762..24934670)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Sirtuin 7 Neighboring gene Cullin 5 Neighboring gene long non-coding RNA:CR45030 Neighboring gene alpha-Mannosidase class I b Neighboring gene Pyruvate dehydrogenase E1 beta subunit

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Loss of Bicra impairs Drosophila learning and choice abilities. Sun Y, et al. Neurosci Lett, 2022 Jan 19. PMID 34974109
    2. Using natural variation in Drosophila to discover previously unknown endoplasmic reticulum stress genes. Chow CY, et al. Proc Natl Acad Sci U S A, 2013 May 28. PMID 23667151, Free PMC Article
    3. Concentric zones, cell migration and neuronal circuits in the Drosophila visual center. Hasegawa E, et al. Development, 2011 Mar. PMID 21303851
    4. Wnt pathway activation increases hypoxia tolerance during development. Gersten M, et al. PLoS One, 2014. PMID 25093834, Free PMC Article
    5. BICRA, a SWI/SNF Complex Member, Is Associated with BAF-Disorder Related Phenotypes in Humans and Model Organisms. Barish S, et al. Am J Hum Genet, 2020 Dec 3. PMID 33232675, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Loss of Bicra impairs Drosophila learning and choice abilities.
      Title: Loss of Bicra impairs Drosophila learning and choice abilities.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: 29079439-29080748 mobile_element_type = transposon:FB{}1449

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to endoplasmic reticulum stress HMP PubMed 
    Component Evidence Code Pubs
    part_of SWI/SNF complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of brahma complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    BRD4 interacting chromatin remodeling complex associated protein
    Names
    Bicra-PA
    Bicra-PB
    Bicra-PC
    Bicra-PD
    CG11873-PA
    CG11873-PB
    CG11873-PC
    CG11873-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      29063040..29108948
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001276122.1 → NP_001263051.1  BRD4 interacting chromatin remodeling complex associated protein, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001263051.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KI51
      Conserved Domains (1) summary
      pfam15249
      Location:2170 → 2271
      GLTSCR1; Conserved region of unknown function on GLTSCR protein

    2. NM_143409.4 → NP_651666.2  BRD4 interacting chromatin remodeling complex associated protein, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651666.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VAP9
      Conserved Domains (1) summary
      pfam15249
      Location:2170 → 2271
      GLTSCR1; Conserved region of unknown function on GLTSCR protein

    3. NM_001276124.1 → NP_001263053.1  BRD4 interacting chromatin remodeling complex associated protein, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001263053.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VAP9
      Conserved Domains (1) summary
      pfam15249
      Location:2170 → 2271
      GLTSCR1; Conserved region of unknown function on GLTSCR protein

    4. NM_001276123.1 → NP_001263052.1  BRD4 interacting chromatin remodeling complex associated protein, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001263052.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KI07, B5X552
      Conserved Domains (1) summary
      pfam15249
      Location:1878 → 1979
      GLTSCR1; Conserved region of unknown function on GLTSCR protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KI07 A0A0B4KI07
    A0A0B4KI51 A0A0B4KI51
    Q9VAP9 Q9VAP9

    Gene LinkOut

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