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    HmgZ HMG protein Z [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37480, updated on 27-Dec-2024

    Summary

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    Official Symbol
    HmgZprovided by FlyBase
    Official Full Name
    HMG protein Zprovided by FlyBase
    Primary source
    FLYBASE:FBgn0010228
    Locus tag
    Dmel_CG17921
    See related
    AllianceGenome:FB:FBgn0010228
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-EST:Liang-1.58; BcDNA:RE28596; CG17921; clone 1.58; dHMG-Z; Dmel\CG17921; HMG Z; hmg-Z; HMG-Z; HMG1; hmgz; HMGZ
    Summary
    Predicted to enable DNA binding activity, bending. Predicted to be involved in regulation of transcription by RNA polymerase II. Is expressed in several structures, including central brain primordium; embryonic/larval midgut; ganglia; and ventral nerve cord primordium. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See HmgZ in Genome Data Viewer
    Location:
    57F9-57F10; 2-96 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (21697488..21707861, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (17584993..17595366, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Translocase of inner membrane 10 Neighboring gene uncharacterized protein Neighboring gene Phosphopantothenoylcysteine decarboxylase Neighboring gene Cyclic nucleotide-gated ion channel subunit B Neighboring gene High mobility group protein D Neighboring gene long non-coding RNA:CR44749 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Insect proteins homologous to mammalian high mobility group protein 1. Characterization and DNA-binding properties. Wiśniewski JR, et al. J Biol Chem, 1992 Aug 25. PMID 1512255
    2. dHMG-Z, a second HMG-1-related protein in Drosophila melanogaster. Ner SS, et al. Nucleic Acids Res, 1993 Sep 11. PMID 8414994, Free PMC Article
    3. DNA bending induced by high mobility group proteins studied by fluorescence resonance energy transfer. Lorenz M, et al. Biochemistry, 1999 Sep 14. PMID 10508419
    4. Alterations in titer and distribution of high mobility group proteins during embryonic development of Drosophila melanogaster. Renner U, et al. Biochim Biophys Acta, 2000 Jun 1. PMID 10806344
    5. Constitutive phosphorylation of the acidic tails of the high mobility group 1 proteins by casein kinase II alters their conformation, stability, and DNA binding specificity. Wiśniewski JR, et al. J Biol Chem, 1999 Jul 16. PMID 10400623

    See all (71) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A major function of the HMGZ protein in Drosophila is to participate in Brahma-dependent chromatin remodeling at a specific subset of Brahma-dependent promoters.
      Title: High mobility group proteins HMGD and HMGZ interact genetically with the Brahma chromatin remodeling complex in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding, bending IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    HMG protein Z
    Names
    CG17921-PA
    CG17921-PB
    CG17921-PC
    CG17921-PD
    HmgZ-PA
    HmgZ-PB
    HmgZ-PC
    HmgZ-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      21697488..21707861 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_166476.2 → NP_726106.1  HMG protein Z, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726106.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q06943, Q0E8Z4, Q9W2D4
      UniProtKB/TrEMBL
      A0A0B4LG36
      Related
      FBpp0071591
      Conserved Domains (1) summary
      pfam00505
      Location:6 → 71
      HMG_box; HMG (high mobility group) box

    2. NM_001299765.1 → NP_001286694.1  HMG protein Z, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286694.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q06943, Q0E8Z4, Q9W2D4
      UniProtKB/TrEMBL
      A0A0B4LG36
      Conserved Domains (1) summary
      pfam00505
      Location:6 → 71
      HMG_box; HMG (high mobility group) box

    3. NM_001299766.1 → NP_001286695.1  HMG protein Z, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286695.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q06943, Q0E8Z4, Q9W2D4
      UniProtKB/TrEMBL
      A0A0B4LG36
      Conserved Domains (1) summary
      pfam00505
      Location:6 → 71
      HMG_box; HMG (high mobility group) box

    4. NM_166477.2 → NP_726107.1  HMG protein Z, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726107.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q06943, Q0E8Z4, Q9W2D4
      UniProtKB/TrEMBL
      A0A0B4LG36
      Related
      FBpp0071590
      Conserved Domains (1) summary
      pfam00505
      Location:6 → 71
      HMG_box; HMG (high mobility group) box
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LG36 A0A0B4LG36
    Q06943.1 Q06943

    Gene LinkOut

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