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    Snp Snipper [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37511, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Snpprovided by FlyBase
    Official Full Name
    Snipperprovided by FlyBase
    Primary source
    FLYBASE:FBgn0265192
    Locus tag
    Dmel_CG44248
    See related
    AllianceGenome:FB:FBgn0265192
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11478; CG30327; CG42257; CG44248; CG6393; Dmel\CG44248
    Old locus tag
    Dmel_CG30327; Dmel_CG42257; Dmel_CG6393
    Summary
    Enables 3'-5'-RNA exonuclease activity; double-stranded DNA 3'-5' DNA exonuclease activity; and single-stranded DNA 3'-5' DNA exonuclease activity. Predicted to be involved in exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Is expressed in several structures, including adult head; embryonic anal pad; embryonic main segment of Malpighian tubule; embryonic/larval midgut primordium; and visceral mesoderm derivative. Orthologous to human ERI2 (ERI1 exoribonuclease family member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Snp in Genome Data Viewer
    Location:
    58B1-58B2; 2-98 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (22060950..22069757)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (17948455..17957262)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Protein phosphatase D5 Neighboring gene Gustatory receptor-like 58a Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Snipper, an Eri1 homologue, affects histone mRNA abundance and is crucial for normal Drosophila melanogaster development. Alexiadis A, et al. FEBS Lett, 2017 Jul. PMID 28626879
    2. Genetic and biochemical characterization of Drosophila Snipper: A promiscuous member of the metazoan 3'hExo/ERI-1 family of 3' to 5' exonucleases. Kupsco JM, et al. RNA, 2006 Dec. PMID 17135487, Free PMC Article
    3. Ttm50 facilitates calpain activation by anchoring it to calcium stores and increasing its sensitivity to calcium. Metwally E, et al. Cell Res, 2021 Apr. PMID 32848200, Free PMC Article
    4. The Conserved RNA Exonuclease Rexo5 Is Required for 3' End Maturation of 28S rRNA, 5S rRNA, and snoRNAs. Gerstberger S, et al. Cell Rep, 2017 Oct 17. PMID 29045842, Free PMC Article
    5. Developmentally regulated alternate 3' end cleavage of nascent transcripts controls dynamic changes in protein expression in an adult stem cell lineage. Berry CW, et al. Genes Dev, 2022 Aug 1. PMID 36175033, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Snp protects the 3'-ends of histone mRNAs
      Title: Snipper, an Eri1 homologue, affects histone mRNA abundance and is crucial for normal Drosophila melanogaster development.
    2. This gene encodes Snipper (Snp), a highly active 3-prime to 5-prime exonuclease with broad substrate specificity. This paper defines a new subclass of exonucleases called the 3'hExo/ERI-1 subfamily of DEDDh nucleases.
      Title: Genetic and biochemical characterization of Drosophila Snipper: A promiscuous member of the metazoan 3'hExo/ERI-1 family of 3' to 5' exonucleases.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 3'-5'-RNA exonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3'-5'-RNA exonuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 3'-5'-RNA exonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables double-stranded DNA 3'-5' DNA exonuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables single-stranded DNA 3'-5' DNA exonuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    NOT involved_in histone mRNA catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    snipper
    Names
    CG44248-PD
    CG44248-PE
    CG44248-PF
    CG44248-PG
    Snp-PD
    Snp-PE
    Snp-PF
    Snp-PG
    NP_611632.3
    NP_726149.1
    NP_726150.1
    NP_726151.3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      22060950..22069757
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137788.4 → NP_611632.3  snipper, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611632.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A8WHF7, Q95RQ4, Q9W2A1
      Related
      FBpp0308244
      Conserved Domains (1) summary
      cd06133
      Location:65 → 256
      ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins

    2. NM_166502.3 → NP_726150.1  snipper, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726150.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W2A1
      Related
      FBpp0308245
      Conserved Domains (1) summary
      cd06133
      Location:7 → 198
      ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins

    3. NM_166503.3 → NP_726151.3  snipper, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726151.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W2A1
      Conserved Domains (1) summary
      cd06133
      Location:7 → 198
      ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins

    4. NM_166501.3 → NP_726149.1  snipper, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726149.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W2A1
      Related
      FBpp0308246
      Conserved Domains (1) summary
      cd06133
      Location:7 → 198
      ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q95RQ4.1 Q95RQ4

    Gene LinkOut

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