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    nAChRalpha7 nicotinic Acetylcholine Receptor alpha7 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32928, updated on 4-Jan-2025

    Summary

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    Official Symbol
    nAChRalpha7provided by FlyBase
    Official Full Name
    nicotinic Acetylcholine Receptor alpha7provided by FlyBase
    Primary source
    FLYBASE:FBgn0086778
    Locus tag
    Dmel_CG32538
    See related
    AllianceGenome:FB:FBgn0086778
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    AcR-Dalpha7; CG32538; CG8082; CG8109; CT24218; Da7; Dalpha7; Dalpha7 nAChR; Dalpha7-nAChR; Dalpha7nAChRs; Dmel\CG32538; gfa; gfA; jpl; nAChR; nAChR-Dalpha7; nAChR-gfa; nAchRa7; nAcRalpha-18C; nAcRalpha-7; nAcRalpha18C; nj507; nj520; nj522; nj54; nj75
    Summary
    Enables acetylcholine-gated monoatomic cation-selective channel activity. Involved in several processes, including chemical synaptic transmission; jump response; and visual behavior. Located in dendritic spine and postsynaptic density. Part of acetylcholine-gated channel complex. Is expressed in adult head; adult periesophageal neuropils; antennal mechanosensory and motor center; synaptic neuropil domain; and visual system neurons. Human ortholog(s) of this gene implicated in chronic obstructive pulmonary disease; esophagus squamous cell carcinoma; respiratory system cancer (multiple); and schizophrenia. Orthologous to human CHRFAM7A (CHRNA7 (exons 5-10) and FAM7A (exons A-E) fusion) and CHRNA7 (cholinergic receptor nicotinic alpha 7 subunit). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    all
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    Genomic context

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    See nAChRalpha7 in Genome Data Viewer
    Location:
    18C2-18C3; 1-62 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (19327075..19348447, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (19221108..19242480, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene small non-coding RNA 763 Neighboring gene uncharacterized protein Neighboring gene outsiders Neighboring gene kekkon 5 Neighboring gene uncharacterized protein Neighboring gene narya

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. New tools for targeted disruption of cholinergic synaptic transmission in Drosophila melanogaster. Mejia M, et al. PLoS One, 2013. PMID 23737994, Free PMC Article
    2. In vivo and in vitro testing of native α-conotoxins from the injected venom of Conus purpurascens. Hoggard MF, et al. Neuropharmacology, 2017 Dec. PMID 28917942
    3. A Drosophila model for developmental nicotine exposure. Velazquez-Ulloa NA. PLoS One, 2017. PMID 28498868, Free PMC Article
    4. Inhibition of cholinergic pathways in Drosophila melanogaster by α-conotoxins. Heghinian MD, et al. FASEB J, 2015 Mar. PMID 25466886, Free PMC Article
    5. A novel approach for in vivo screening of toxins using the Drosophila Giant Fiber circuit. Mejia M, et al. Toxicon, 2010 Dec. PMID 20723555, Free PMC Article

    See all (128) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Overexpression of postsynaptic Dalpha7nAChRs caused a significant increase in the length of proximal dendrites, i.e., the cholinergic dendritic domain.
      Title: Intra-neuronal Competition for Synaptic Partners Conserves the Amount of Dendritic Building Material.
    2. essential role for the Dalpha7 nicotinic acetylcholine receptor in giant fiber-mediated escape in Drosophila
      Title: The nicotinic acetylcholine receptor Dalpha7 is required for an escape behavior in Drosophila.
    3. In addition to the formation of homomeric nAChR complexes, evidence has been obtained from both radioligand binding and co-immunoprecipitation studies for the co-assembly of Dalpha6 and Dalpha7 into heteromeric cell surface complexes
      Title: Molecular characterization of Dalpha6 and Dalpha7 nicotinic acetylcholine receptor subunits from Drosophila: formation of a high-affinity alpha-bungarotoxin binding site revealed by expression of subunit chimeras.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: c19330843-19330629 mobile_element_type = transposon:INE-1{}5595

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables acetylcholine-gated monoatomic cation-selective channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables acetylcholine-gated monoatomic cation-selective channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables excitatory extracellular ligand-gated monoatomic ion channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chemical synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in excitatory postsynaptic potential IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in jump response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in monoatomic cation transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in monoatomic ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of membrane potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in synaptic transmission, cholinergic IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in visual behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of acetylcholine-gated channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of acetylcholine-gated channel complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in dendritic spine IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    nicotinic acetylcholine receptor alpha7
    Names
    CG32538-PA
    CG32538-PD
    CG32538-PE
    CG32538-PF
    Dalpha7
    Dalpha7 subunit of the acetylcholine receptor
    Dalpha7 subunit of the nicotinic acetylcholine receptor
    giant fiber A
    giant fibre A
    jumpless
    nAChRalpha7-PA
    nAChRalpha7-PD
    nAChRalpha7-PE
    nAChRalpha7-PF
    nicotinic acetylcholine receptor alpha 18C
    non-jumper-507
    non-jumper-520
    non-jumper-522
    non-jumper-54
    non-jumper-75
    shaker cognate L

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      19327075..19348447 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_167645.4 → NP_728239.3  nicotinic acetylcholine receptor alpha7, isoform D [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A4GXC7, Q7KUV2, Q9VWI9
      Conserved Domains (3) summary
      TIGR00860
      Location:59 → 548
      LIC; Cation transporter family protein
      pfam02931
      Location:61 → 268
      Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
      pfam02932
      Location:275 → 552
      Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

    2. NM_001298507.1 → NP_001285436.1  nicotinic acetylcholine receptor alpha7, isoform F [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A4GXC7, Q7KUV2, Q9VWI9
      Conserved Domains (3) summary
      TIGR00860
      Location:59 → 548
      LIC; Cation transporter family protein
      pfam02931
      Location:61 → 268
      Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
      pfam02932
      Location:275 → 552
      Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

    3. NM_206791.3 → NP_996514.1  nicotinic acetylcholine receptor alpha7, isoform A [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A4GXC7, Q7KUV2, Q9VWI9
      Conserved Domains (3) summary
      TIGR00860
      Location:59 → 548
      LIC; Cation transporter family protein
      pfam02931
      Location:61 → 268
      Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
      pfam02932
      Location:275 → 552
      Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

    4. NM_001169324.2 → NP_001162795.1  nicotinic acetylcholine receptor alpha7, isoform E [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A4GXC7, E1JJR2
      Conserved Domains (3) summary
      TIGR00860
      Location:59 → 548
      LIC; Cation transporter family protein
      pfam02931
      Location:61 → 268
      Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
      pfam02932
      Location:275 → 552
      Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E1JJR2 E1JJR2
    Q86MN7 Q86MN7
    Q8T5F4 Q8T5F4
    Q9VWI9 Q9VWI9

    Gene LinkOut

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