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    CG10177 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42772, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG10177provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039083
    Locus tag
    Dmel_CG10177
    See related
    AllianceGenome:FB:FBgn0039083
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG10177
    Summary
    Predicted to enable protein serine/threonine kinase activity. Involved in Golgi organization and negative regulation of cell size. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in colorectal cancer; depressive disorder; and spermatogenic failure 93. Orthologous to human STK33 (serine/threonine kinase 33). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG10177 in Genome Data Viewer
    Location:
    95A1-95A1; 3-80 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (23520146..23521583, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (19345868..19347305, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Inwardly rectifying potassium channel 2 Neighboring gene uncharacterized protein Neighboring gene UDP-glycosyltransferase family 303 member B3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. ERK7 is a negative regulator of protein secretion in response to amino-acid starvation by modulating Sec16 membrane association. Zacharogianni M, et al. EMBO J, 2011 Aug 16. PMID 21847093, Free PMC Article
    2. A directed miniscreen for genes involved in the Drosophila anti-parasitoid immune response. Howell L, et al. Immunogenetics, 2012 Feb. PMID 21947570
    3. Genome-wide RNAi screening implicates the E3 ubiquitin ligase Sherpa in mediating innate immune signaling by Toll in Drosophila adults. Kanoh H, et al. Sci Signal, 2015 Oct 27. PMID 26508789
    4. An RNAi screen of the kinome in epithelial follicle cells of the Drosophila melanogaster ovary reveals genes required for proper germline death and clearance. Lebo DPV, et al. G3 (Bethesda), 2021 Feb 9. PMID 33693600, Free PMC Article
    5. Wake-up-call, a lin-52 paralogue, and Always early, a lin-9 homologue physically interact, but have opposing functions in regulating testis-specific gene expression. Doggett K, et al. Dev Biol, 2011 Jul 15. PMID 21570388, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic DNA damage checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of cell size IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG10177-PA
    MLCK-like
    NP_651150.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      23520146..23521583 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142893.2 → NP_651150.1  uncharacterized protein Dmel_CG10177 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651150.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MZC6, Q9VCL7
      Related
      FBpp0083816
      Conserved Domains (3) summary
      smart00220
      Location:164 → 409
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      smart00537
      Location:18 → 108
      DCX; Domain in the Doublecortin (DCX) gene product
      cl21453
      Location:164 → 403
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MZC6 Q8MZC6
    Q9VCL7 Q9VCL7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
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