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    CG9886 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33431, updated on 27-Dec-2024

    Summary

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    Official Symbol
    CG9886provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0031428
    Locus tag
    Dmel_CG9886
    See related
    AllianceGenome:FB:FBgn0031428
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    AAF51252; Dmel\CG9886
    Summary
    Predicted to enable glycerate kinase activity. Predicted to be involved in protein phosphorylation. Predicted to be located in cytosol and mitochondrion. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in D-glyceric aciduria. Orthologous to human GLYCTK (glycerate kinase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG9886 in Genome Data Viewer
    Location:
    22E1-22E1; 2-6 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (2420830..2424647)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (2420830..2424647)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44912

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Glycerate kinase of the hyperthermophilic archaeon Thermoproteus tenax: new insights into the phylogenetic distribution and physiological role of members of the three different glycerate kinase classes. Kehrer D, et al. BMC Genomics, 2007 Aug 31. PMID 17764545, Free PMC Article
    2. The expression pattern of the Drosophila vesicular glutamate transporter: a marker protein for motoneurons and glutamatergic centers in the brain. Mahr A, et al. Gene Expr Patterns, 2006 Mar. PMID 16378756
    3. Lsd1 restricts the number of germline stem cells by regulating multiple targets in escort cells. Eliazer S, et al. PLoS Genet, 2014 Mar. PMID 24625679, Free PMC Article
    4. Cross-species genetic screens to identify kinase targets for APP reduction in Alzheimer's disease. Huichalaf CH, et al. Hum Mol Genet, 2019 Jun 15. PMID 30753434, Free PMC Article
    5. Genomic regulatory blocks underlie extensive microsynteny conservation in insects. Engström PG, et al. Genome Res, 2007 Dec. PMID 17989259, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables glycerate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glycerate kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycerate kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG9886-PA
    CG9886-PB
    NP_001259941.1
    NP_608684.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      2420830..2424647
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273012.1 → NP_001259941.1  uncharacterized protein Dmel_CG9886, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259941.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VQC4
      UniProtKB/TrEMBL
      M9PB12
      Conserved Domains (3) summary
      COG2379
      Location:12 → 487
      GckA; Glycerate-2-kinase [Carbohydrate transport and metabolism]
      pfam05161
      Location:367 → 480
      MOFRL; MOFRL family
      pfam13660
      Location:10 → 261
      DUF4147; Domain of unknown function (DUF4147)

    2. NM_134840.3 → NP_608684.1  uncharacterized protein Dmel_CG9886, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608684.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VQC4
      UniProtKB/TrEMBL
      M9PB12
      Related
      FBpp0077450
      Conserved Domains (3) summary
      COG2379
      Location:12 → 487
      GckA; Glycerate-2-kinase [Carbohydrate transport and metabolism]
      pfam05161
      Location:367 → 480
      MOFRL; MOFRL family
      pfam13660
      Location:10 → 261
      DUF4147; Domain of unknown function (DUF4147)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PB12 M9PB12
    Q9VQC4.1 Q9VQC4

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