Idh Isocitrate dehydrogenase [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Idhprovided by FlyBase
Official Full Name: Isocitrate dehydrogenaseprovided by FlyBase
Primary source: FLYBASE:FBgn0001248
Locus tag: Dmel_CG7176
See related: AllianceGenome:FB:FBgn0001248
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG7176; cIdh; CT22171; dIDH2; Dmel\CG7176; ICDH; idh; IDH; IDH (CG7176); Idh-NADP; IDH-NADP; IDH1; IDH2; isocitrate dehydrogenase; l(3)L3852
Summary: Enables isocitrate dehydrogenase (NADP+) activity. Involved in cellular response to oxidative stress and isocitrate metabolic process. Is active in cytosol and mitochondrion. Is expressed in several structures, including adult head; adult heart; embryonic anal pad; germline cell; and gut section. Used to study D-2-hydroxyglutaric aciduria and cancer. Human ortholog(s) of this gene implicated in autoimmune disease; hematologic cancer (multiple); hepatocellular clear cell carcinoma; and high grade glioma (multiple). Orthologous to human IDH1 (isocitrate dehydrogenase (NADP(+)) 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 66C8-66C8; 3-24 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (8356404..8360906, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (8349504..8354006, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

trimethyl isocitrate (TIC), a cell permeable isocitrate, protected mammalian DJ-1 null DA cells from oxidative stress in an IDH-dependent manner. These results suggest that isocitrate and its derivatives are novel treatments for Parkinson's disease associated with DJ-1 dysfunction.
Title: Isocitrate protects DJ-1 null dopaminergic cells from oxidative stress through NADP+-dependent isocitrate dehydrogenase (IDH).
We identified the fly homolog of D-2-hydroxyglutaric acid dehydrogenase (CG3835), which metabolizes D-2HG, and showed that coexpression of this enzyme with mutant Idh abolishes mutant Idh-associated phenotype
Title: Genetic dissection of leukemia-associated IDH1 and IDH2 mutants and D-2-hydroxyglutarate in Drosophila.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables NAD binding	IEA Inferred from Electronic Annotation more info
enables isocitrate dehydrogenase (NADP+) activity	IBA Inferred from Biological aspect of Ancestor more info
enables isocitrate dehydrogenase (NADP+) activity	IDA Inferred from Direct Assay more info	PubMed
enables isocitrate dehydrogenase (NADP+) activity	IEA Inferred from Electronic Annotation more info
enables isocitrate dehydrogenase (NADP+) activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in NADP metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in isocitrate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in isocitrate metabolic process	IDA Inferred from Direct Assay more info
involved_in isocitrate metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	IDA Inferred from Direct Assay more info	PubMed
is_active_in mitochondrial matrix	IC Inferred by Curator more info	PubMed
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
is_active_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
is_active_in peroxisome	IBA Inferred from Biological aspect of Ancestor more info
located_in peroxisome	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: isocitrate dehydrogenase

Names: CG7176-PA; CG7176-PB; CG7176-PC; CG7176-PD; CG7176-PF; CG7176-PG; CG7176-PI; CG7176-PJ; CG7176-PK; ISOCITRATE DEHYDROGENASE; Idh-PA; Idh-PB; Idh-PC; Idh-PD; Idh-PF; Idh-PG; Idh-PI; Idh-PJ; Idh-PK; NADP-IDH; isocitrate dehydrogenase (NADP[+]); isocitrate dehydrogenase (cytosolic); isocitrate dehydrolase

NP_001137910.2

EC 1.1.1.-

EC 1.1.1.42

NP_001137911.1

EC 1.1.1.-

EC 1.1.1.42

NP_652044.1

EC 1.1.1.-

EC 1.1.1.42

NP_729366.1

EC 1.1.1.-

EC 1.1.1.42

NP_729367.1

EC 1.1.1.-

EC 1.1.1.42

NP_729368.1

EC 1.1.1.-

EC 1.1.1.42

NP_729369.2

EC 1.1.1.-

EC 1.1.1.42

NP_729370.1

EC 1.1.1.-

EC 1.1.1.42

NP_788476.1

EC 1.1.1.-

EC 1.1.1.42

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

8356404..8360906 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_168267.2 → NP_729368.1 isocitrate dehydrogenase, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_729368.1

Status: REVIEWED

UniProtKB/TrEMBL

C8VV61, Q7KUB0

Related

FBpp0076390

Conserved Domains (1) summary

PTZ00435
Location:1 → 411

PTZ00435; isocitrate dehydrogenase; Provisional
NM_168269.2 → NP_729370.1 isocitrate dehydrogenase, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_729370.1

Status: REVIEWED

UniProtKB/TrEMBL

C8VV61, Q7KUB0

Related

FBpp0076391

Conserved Domains (1) summary

PTZ00435
Location:1 → 411

PTZ00435; isocitrate dehydrogenase; Provisional
NM_168268.3 → NP_729369.2 isocitrate dehydrogenase, isoform I [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_729369.2

Status: REVIEWED

UniProtKB/TrEMBL

C8VV61, Q961X1, Q9VSI4, Q9VSI5, Q9VSI6

Conserved Domains (1) summary

PTZ00435
Location:35 → 445

PTZ00435; isocitrate dehydrogenase; Provisional
NM_176298.2 → NP_788476.1 isocitrate dehydrogenase, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_788476.1

Status: REVIEWED

UniProtKB/TrEMBL

C8VV61, Q961X1, Q9VSI4, Q9VSI5, Q9VSI6

Related

FBpp0076396

Conserved Domains (1) summary

PTZ00435
Location:35 → 445

PTZ00435; isocitrate dehydrogenase; Provisional
NM_001144439.2 → NP_001137911.1 isocitrate dehydrogenase, isoform J [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001137911.1

Status: REVIEWED

UniProtKB/TrEMBL

C8VV61, Q961X1, Q9VSI4, Q9VSI5, Q9VSI6

Conserved Domains (1) summary

PTZ00435
Location:35 → 445

PTZ00435; isocitrate dehydrogenase; Provisional
NM_168265.2 → NP_729366.1 isocitrate dehydrogenase, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_729366.1

Status: REVIEWED

UniProtKB/TrEMBL

C8VV61, Q961X1, Q9VSI4, Q9VSI5, Q9VSI6

Related

FBpp0076392

Conserved Domains (1) summary

PTZ00435
Location:35 → 445

PTZ00435; isocitrate dehydrogenase; Provisional
NM_143787.3 → NP_652044.1 isocitrate dehydrogenase, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_652044.1

Status: REVIEWED

UniProtKB/TrEMBL

C8VV61, Q7KUB1

Related

FBpp0076393

Conserved Domains (1) summary

PTZ00435
Location:54 → 464

PTZ00435; isocitrate dehydrogenase; Provisional
NM_001144438.2 → NP_001137910.2 isocitrate dehydrogenase, isoform K [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001137910.2

Status: REVIEWED

UniProtKB/TrEMBL

B7Z0E0, C8VV61

Conserved Domains (1) summary

PTZ00435
Location:63 → 474

PTZ00435; isocitrate dehydrogenase; Provisional
NM_168266.2 → NP_729367.1 isocitrate dehydrogenase, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_729367.1

Status: REVIEWED

UniProtKB/TrEMBL

C8VV61, Q8IQA7

Related

FBpp0076394

Conserved Domains (1) summary

PTZ00435
Location:21 → 432

PTZ00435; isocitrate dehydrogenase; Provisional