run runt [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: runprovided by FlyBase
Official Full Name: runtprovided by FlyBase
Primary source: FLYBASE:FBgn0003300
Locus tag: Dmel_CG1849
See related: AllianceGenome:FB:FBgn0003300
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 1; 2; AA33; CG1849; Dmel\CG1849; l(1)19Ea; l(1)AA33; l(1)B2/13.1; l(1)LB9; LB5; leg; lLB5; P235; Rnt; Run; RUN; runt; Runt
Summary: Enables DNA-binding transcription factor activity and sequence-specific DNA binding activity. Involved in several processes, including axon guidance; germ-band extension; and regulation of DNA-templated transcription. Located in nucleus. Is expressed in several structures, including anlage in statu nascendi; head epidermis primordium; inner photoreceptor cell; larval neurons; and somatic precursor cell. Human ortholog(s) of this gene implicated in several diseases, including breast cancer (multiple); female reproductive organ cancer (multiple); lung non-small cell carcinoma; osteochondrodysplasia (multiple); and pancreatic cancer. Orthologous to several human genes including RUNX2 (RUNX family transcription factor 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 19E2-19E2; 1-65 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (20690670..20697321)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (20561697..20568348)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A dual role for DNA binding by Runt in activation and repression of sloppy paired transcription.
Title: A dual role for DNA binding by Runt in activation and repression of sloppy paired transcription.
Runt-dependent regulation in the Drosophila blastoderm embryo relies on unique, target-gene-specific molecular interactions.
Title: Hairless is a cofactor for Runt-dependent transcriptional regulation.
there are two distinct steps in the repression of engrailed by Runt
Title: Distinct in vivo requirements for establishment versus maintenance of transcriptional repression.
Lilli plays an architectural role in facilitating transcriptional activation that depends both on the target gene and the developmental context
Title: The HMG-box protein Lilliputian is required for Runt-dependent activation of the pair-rule gene fushi-tarazu.
Contrasting responses of different downstream targets to Runt in the presence or absence of Ftz is thus central to the combinatorial logic of the pair-rule to segment-polarity transition.
Title: Ftz modulates Runt-dependent activation and repression of segment-polarity gene transcription.
These proteins provide a paradigm for understanding DNA-binding-independent regulation by developmentally important transcription factors.
Title: A DNA-binding-independent pathway of repression by the Drosophila Runt protein.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in eye morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germ-band extension	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in periodic partitioning by pair rule gene	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in sex determination, establishment of X:A ratio	TAS Traceable Author Statement more info	PubMed
involved_in ventral cord development	TAS Traceable Author Statement more info	PubMed