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    rdhB retinol dehydrogenase B [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42614, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rdhBprovided by FlyBase
    Official Full Name
    retinol dehydrogenase Bprovided by FlyBase
    Primary source
    FLYBASE:FBgn0038946
    Locus tag
    Dmel_CG7077
    See related
    AllianceGenome:FB:FBgn0038946
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG7077; Dmel\CG7077; RdhB
    Summary
    Enables all-trans-retinol dehydrogenase (NAD+) activity. Involved in rhodopsin biosynthetic process. Is expressed in adult head; eye; pigment cell; and retina. Orthologous to human DHRS11 (dehydrogenase/reductase 11). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See rdhB in Genome Data Viewer
    Location:
    94A5-94A5; 3-74 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (22351696..22356264)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (18177418..18181986)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR46054 Neighboring gene uncharacterized protein Neighboring gene Secretion-associated Ras-related 1 Neighboring gene Jumonji domain containing 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Drosophila visual cycle and de novo chromophore synthesis depends on rdhB. Wang X, et al. J Neurosci, 2012 Mar 7. PMID 22399771, Free PMC Article
    2. LOVIT Is a Putative Vesicular Histamine Transporter Required in Drosophila for Vision. Xu Y, et al. Cell Rep, 2019 Apr 30. PMID 31042461
    3. Intercellular chaperone transmission via exosomes contributes to maintenance of protein homeostasis at the organismal level. Takeuchi T, et al. Proc Natl Acad Sci U S A, 2015 May 12. PMID 25918398, Free PMC Article
    4. Histamine Recycling Is Mediated by CarT, a Carcinine Transporter in Drosophila Photoreceptors. Xu Y, et al. PLoS Genet, 2015 Dec. PMID 26713872, Free PMC Article
    5. Quantitative proteomic analysis of Parkin substrates in Drosophila neurons. Martinez A, et al. Mol Neurodegener, 2017 Apr 11. PMID 28399880, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables all-trans-retinol dehydrogenase (NAD+) activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in rhodopsin biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    retinol dehydrogenase B
    Names
    CG7077-PA
    CG7077-PB
    rdhB-PA
    rdhB-PB
    NP_001262831.1
    NP_651024.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      22351696..22356264
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001275902.1 → NP_001262831.1  retinol dehydrogenase B, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262831.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VD30
      Conserved Domains (2) summary
      cd05343
      Location:4 → 244
      Mgc4172-like_SDR_c; human Mgc4172-like, classical (c) SDRs
      COG4221
      Location:9 → 241
      YdfG; NADP-dependent 3-hydroxy acid dehydrogenase YdfG [Energy production and conversion]

    2. NM_142767.2 → NP_651024.1  retinol dehydrogenase B, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651024.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VD30
      Related
      FBpp0083603
      Conserved Domains (2) summary
      cd05343
      Location:4 → 244
      Mgc4172-like_SDR_c; human Mgc4172-like, classical (c) SDRs
      COG4221
      Location:9 → 241
      YdfG; NADP-dependent 3-hydroxy acid dehydrogenase YdfG [Energy production and conversion]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VD30 Q9VD30

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