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    dsf dissatisfaction [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33823, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dsfprovided by FlyBase
    Official Full Name
    dissatisfactionprovided by FlyBase
    Primary source
    FLYBASE:FBgn0015381
    Locus tag
    Dmel_CG9019
    See related
    AllianceGenome:FB:FBgn0015381
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9019; Dmel\CG9019; Dsf; DSF; NR2E4
    Summary
    Enables DNA-binding transcription repressor activity, RNA polymerase II-specific. Involved in several processes, including egg-laying behavior; mating behavior, sex discrimination; and regulation of female receptivity. Is expressed in adult brain; anterior protocerebral neuromere; eye disc; ganglia; and salivary gland. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See dsf in Genome Data Viewer
    Location:
    26A1-26A2; 2-18 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (5925937..5939261)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (5925937..5939261)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene blue cheese Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR43926 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45288 Neighboring gene long non-coding RNA:CR45289

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Developmental remodeling repurposes larval neurons for sexual behaviors in adult Drosophila. Diamandi JA, et al. Curr Biol, 2024 Mar 25. PMID 38377996
    2. Fine-scale genetic analysis of species-specific female preference in Drosophila simulans. Laturney M, et al. J Evol Biol, 2012 Sep. PMID 22694106
    3. DSF nuclear receptor acts as a repressor in culture and in vivo. Pitman JL, et al. Dev Biol, 2002 May 15. PMID 11977984
    4. dissatisfaction, a gene involved in sex-specific behavior and neural development of Drosophila melanogaster. Finley KD, et al. Proc Natl Acad Sci U S A, 1997 Feb 4. PMID 9023356, Free PMC Article
    5. Regulation of Drosophila courtship behavior by the Tlx/tailless-like nuclear receptor, dissatisfaction. Duckhorn JC, et al. Curr Biol, 2022 Apr 25. PMID 35245457

    See all (69) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. DSF nuclear receptor acts as a repressor in culture and in vivo
      Title: DSF nuclear receptor acts as a repressor in culture and in vivo.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nuclear receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nuclear receptor activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables nuclear receptor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables nuclear steroid receptor activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in copulation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in courtship behavior NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in courtship behavior TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in egg-laying behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in egg-laying behavior NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in egg-laying behavior TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in male courtship behavior TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in mating behavior NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in mating behavior, sex discrimination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mating behavior, sex discrimination TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of female receptivity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of female receptivity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of hemocyte proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in sex determination TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in somatic sex determination NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dissatisfaction
    Names
    CG9019-PA
    CG9019-PB
    dsf-PA
    dsf-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      5925937..5939261
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273180.1 → NP_001260109.1  dissatisfaction, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260109.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O96680, Q9VML1
      Conserved Domains (2) summary
      cd06950
      Location:467 → 671
      NR_LBD_Tlx_PNR_like; The ligand binding domain of Tailless-like proteins, orphan nuclear receptors
      cd07163
      Location:5 → 98
      NR_DBD_TLX; DNA-binding domain of Tailless (TLX) is composed of two C4-type zinc fingers

    2. NM_057792.3 → NP_477140.1  dissatisfaction, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477140.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O96680, Q9VML1
      Related
      FBpp0078776
      Conserved Domains (2) summary
      cd06950
      Location:467 → 671
      NR_LBD_Tlx_PNR_like; The ligand binding domain of Tailless-like proteins, orphan nuclear receptors
      cd07163
      Location:5 → 98
      NR_DBD_TLX; DNA-binding domain of Tailless (TLX) is composed of two C4-type zinc fingers
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VML1.1 Q9VML1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools