qvr quiver [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: qvrprovided by FlyBase
Official Full Name: quiverprovided by FlyBase
Primary source: FLYBASE:FBgn0260499
Locus tag: Dmel_CG33472
See related: AllianceGenome:FB:FBgn0260499
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-WO02059370.1; BcDNA:GH06755; CG30032; CG33472; Dmel\CG33472; mdcds_22455; Qvr; qvr/sleepless; sss
Summary: Enables GPI anchor binding activity; acetylcholine receptor inhibitor activity; and potassium channel activator activity. Involved in several processes, including negative regulation of membrane potential; positive regulation of circadian sleep/wake cycle, sleep; and regulation of cholinergic synaptic transmission. Located in external side of plasma membrane. Is expressed in adult antennal nerve; adult head; adult mushroom body; adult protocerebrum; and synaptic neuropil domain. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 47F13-47F13; 2-64 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (11442505..11451604)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (7330010..7339109)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

QVR/SSS, and by extension perhaps other Ly6 proteins, target effector molecules using limited protein motifs.
Title: Structural Analysis and Deletion Mutagenesis Define Regions of QUIVER/SLEEPLESS that Are Responsible for Interactions with Shaker-Type Potassium Channels and Nicotinic Acetylcholine Receptors.
role in controlling excitability and synaptic transmission in fundamental processes of the nervous system such as sleep
Title: SLEEPLESS is a bifunctional regulator of excitability and cholinergic synaptic transmission.
Day-night cycles and the sleep-promoting factor, Sleepless, affect stem cell activity in the Drosophila testis.
Title: Day-night cycles and the sleep-promoting factor, Sleepless, affect stem cell activity in the Drosophila testis.
This study demonstrated that SLEEPLESS (SSS) protein modulates Shaker channel activity, possibly through a direct interaction at the plasma membrane.
Title: Drosophila QVR/SSS modulates the activation and C-type inactivation kinetics of Shaker K(+) channels.
Two different functional states of Shaker I(A) current are observed in qvr larval muscles, as reflected by two distinct components differing in their kinetics of recovery from inactivation and sensitivity to a potassium channel blocker.
Title: Modulation of the frequency response of Shaker potassium channels by the quiver peptide suggesting a novel extracellular interaction mechanism.
The sleepless (sss) gene is required for sleep in Drosophila. It is proposed that SLEEPLESS is a signaling molecule that connects sleep drive to lowered membrane excitability.
Title: Identification of SLEEPLESS, a sleep-promoting factor.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables GPI anchor binding	IDA Inferred from Direct Assay more info	PubMed
enables acetylcholine receptor inhibitor activity	IGI Inferred from Genetic Interaction more info	PubMed
enables potassium channel activator activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of membrane potential	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of circadian sleep/wake cycle, sleep	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of voltage-gated potassium channel activity	IEA Inferred from Electronic Annotation more info
involved_in regulation of circadian sleep/wake cycle, sleep	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of synaptic transmission, cholinergic	IEA Inferred from Electronic Annotation more info
involved_in regulation of synaptic transmission, cholinergic	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sleep	IEA Inferred from Electronic Annotation more info
involved_in sleep	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed