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    Mzt1 Mitotic spindle organizing protein 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 10178948, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Mzt1provided by FlyBase
    Official Full Name
    Mitotic spindle organizing protein 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0261858
    Locus tag
    Dmel_CG42787
    See related
    AllianceGenome:FB:FBgn0261858
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG42787; Dmel\CG42787; mzt1
    Summary
    Enables gamma-tubulin binding activity. Involved in gamma-tubulin complex localization. Located in centriole and centrosome. Part of gamma-tubulin ring complex. Is active in cytosol. Is expressed in gonad and male germline cell. Orthologous to human MZT1 (mitotic spindle organizing protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Mzt1 in Genome Data Viewer
    Location:
    62E1-62E1; 3-3 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (2389265..2389650)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (2389265..2389650)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene mitochondrial ribosomal protein L23 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Supervillin Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Cytochrome P450 4d20

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The gamma-tubulin ring complex: Deciphering the molecular organization and assembly mechanism of a major vertebrate microtubule nucleator. Böhler A, et al. Bioessays, 2021 Aug. PMID 34160844
    2. γ-TuRC Heterogeneity Revealed by Analysis of Mozart1. Tovey CA, et al. Curr Biol, 2018 Jul 23. PMID 29983314, Free PMC Article
    3. Versatile gamma-tubulin complexes contribute to the dynamic organization of MTOCs during Drosophila spermatogenesis. Alzyoud E, et al. Commun Biol, 2024 Oct 24. PMID 39448788, Free PMC Article
    4. Microtubule Organizing Centers Contain Testis-Specific γ-TuRC Proteins in Spermatids of Drosophila. Alzyoud E, et al. Front Cell Dev Biol, 2021. PMID 34660584, Free PMC Article
    5. Identification of novel genes associated with longevity in Drosophila melanogaster - a computational approach. Hall BS, et al. Aging (Albany NY), 2019 Dec 3. PMID 31794428, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables gamma-tubulin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in gamma-tubulin complex localization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in gamma-tubulin complex localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in microtubule nucleation by interphase microtubule organizing center IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic spindle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in centriole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of gamma-tubulin ring complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of gamma-tubulin ring complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of gamma-tubulin ring complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in interphase microtubule organizing center IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in spindle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    mitotic spindle organizing protein 1
    Names
    CG42787-PA
    MOZART1
    Mzt1-PA
    mitotic spindle OrganiZing protein associated with a ring of g-Tubulin

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      2389265..2389650
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001202099.2 → NP_001189028.1  mitotic spindle organizing protein 1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001189028.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6ILY6
      Conserved Domains (1) summary
      pfam12554
      Location:14 → 56
      MOZART1; Mitotic-spindle organizing gamma-tubulin ring associated
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6ILY6 Q6ILY6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials