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    neb nebbish [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35293, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nebprovided by FlyBase
    Official Full Name
    nebbishprovided by FlyBase
    Primary source
    FLYBASE:FBgn0004374
    Locus tag
    Dmel_CG10718
    See related
    AllianceGenome:FB:FBgn0004374
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    38B.10; 38B.12; CG10718; Dm0332; Dmel\CG10718; DmKlp38B; DmNeb; KIF 14; KIF14; KLP 38B; KLP-38B; Klp38; klp38B; Klp38B; KLP38B; l(2)03552; l(2)k00802; l(2)k07614; Mot; Neb; nebb; sl(2)ry; sl(2)ry3; tio
    Summary
    Enables protein phosphatase 1 binding activity. Involved in several processes, including follicle cell of egg chamber development; mitotic cell cycle, embryonic; and mitotic chromosome condensation. Located in heterochromatin. Is expressed in several structures, including follicle cell; ganglia; germline cell; gonad; and imaginal disc. Human ortholog(s) of this gene implicated in Meckel syndrome and primary autosomal recessive microcephaly. Orthologous to human KIF14 (kinesin family member 14). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See neb in Genome Data Viewer
    Location:
    38B3-38B5; 2-54 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (20075757..20089698)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (20075757..20089698)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene brain washing Neighboring gene uncharacterized protein Neighboring gene purple Neighboring gene fledgling of Klp38B Neighboring gene uncharacterized protein Neighboring gene Pyridine nucleotide-disulfide oxidoreductase domain 1 Neighboring gene TBP-associated factor 13 Neighboring gene nessun dorma

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Microtubule motors in mitosis. Sharp DJ, et al. Nature, 2000 Sep 7. PMID 10993066
    2. A chromatin-associated kinesin-related protein required for normal mitotic chromosome segregation in Drosophila. Molina I, et al. J Cell Biol, 1997 Dec 15. PMID 9396743, Free PMC Article
    3. Motor function in the mitotic spindle. Heald R. Cell, 2000 Aug 18. PMID 10966101
    4. Citron kinase controls a molecular network required for midbody formation in cytokinesis. Bassi ZI, et al. Proc Natl Acad Sci U S A, 2013 Jun 11. PMID 23716662, Free PMC Article
    5. Identification of fat-cell enhancer activity in Drosophila melanogaster using P-element enhancer traps. Hoshizaki DK, et al. Genome, 1995 Jun. PMID 7557362

    See all (83) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chromatin binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule motor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables plus-end-directed microtubule motor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein phosphatase 1 binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromosome segregation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in follicle cell of egg chamber development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiotic cell cycle IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in microtubule-based movement IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule-based movement IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in microtubule-based movement ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in mitotic cell cycle, embryonic IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic chromosome condensation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic sister chromatid segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in oogenesis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in heterochromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of kinesin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    nebbish
    Names
    CG10718-PA
    Kinesin-like protein at 38B
    Kinesin3C
    mothra
    neb-PA
    tiovivo
    NP_476817.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      20075757..20089698
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057469.4 → NP_476817.1  nebbish [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476817.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O02030, O16866, O18389, Q9VIP4
      Related
      FBpp0080864
      Conserved Domains (4) summary
      smart00129
      Location:120 → 525
      KISc; Kinesin motor, catalytic domain. ATPase
      cd00060
      Location:634 → 740
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd01365
      Location:119 → 525
      KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
      pfam16183
      Location:524 → 657
      Kinesin_assoc; Kinesin-associated
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O16866 O16866
    O18390 O18390
    Q7JMZ1 Q7JMZ1
    Q7KQ58 Q7KQ58
    Q960F4 Q960F4
    Q9VIP4 Q9VIP4

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