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    Cul2 Cullin 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35420, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cul2provided by FlyBase
    Official Full Name
    Cullin 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0032956
    Locus tag
    Dmel_CG1512
    See related
    AllianceGenome:FB:FBgn0032956
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1512; cul-2; Cul-2; cul2; CUL2; Cullin2; dCul2; DMcul-2; Dmel\CG1512; l(2)02074
    Summary
    Enables ubiquitin ligase complex scaffold activity. Involved in several processes, including growth of a germarium-derived egg chamber; male germ-line cyst encapsulation; and negative regulation of signal transduction. Located in perinuclear region of cytoplasm. Part of Cul2-RING ubiquitin ligase complex. Is expressed in several structures, including antennal disc; egg chamber; eye disc posterior to the morphogenetic furrow; germline cell; and organism subdivision. Orthologous to human CUL2 (cullin 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Cul2 in Genome Data Viewer
    Location:
    39E3-39E6; 2-54 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (21658735..21663698)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (21658735..21663698)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Adenylate cyclase 3 Neighboring gene long non-coding RNA:CR43144 Neighboring gene antisense RNA:CR46066 Neighboring gene uncharacterized protein Neighboring gene small non-coding RNA 254 Neighboring gene eukaryotic translation elongation factor 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. E3 ligase Cul2 mediates Drosophila early germ cell differentiation through targeting Bam. Cai Q, et al. Dev Biol, 2023 Jan. PMID 36423673
    2. Reduction of Cullin-2 in somatic cells disrupts differentiation of germline stem cells in the Drosophila ovary. Ayyub C, et al. Dev Biol, 2015 Sep 15. PMID 26206612
    3. Temporal and spatial expression of the cell-cycle regulator cul-1 in Drosophila and its stimulation by radiation-induced apoptosis. Filippov V, et al. J Exp Biol, 2000 Sep. PMID 10952875
    4. Socs36E limits STAT signaling via Cullin2 and a SOCS-box independent mechanism in the Drosophila egg chamber. Monahan AJ, et al. Mech Dev, 2015 Nov. PMID 26277564
    5. The cullin protein family. Sarikas A, et al. Genome Biol, 2011. PMID 21554755, Free PMC Article

    See all (70) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. contributes mechanistic insight to a Jak/STAT regulatory genetic circuit, and suggests that Socs36E regulates Jak/STAT signaling via a Cul2-dependent mechanism, as well as by a Cullin-independent manner, in vivo
      Title: Socs36E limits STAT signaling via Cullin2 and a SOCS-box independent mechanism in the Drosophila egg chamber.
    2. Cullin-2 protein present in the somatic cells is involved in a non cell-autonomous regulation of the extent of Dpp signaling and thus controls the differentiation of GSCs to cystoblasts
      Title: Reduction of Cullin-2 in somatic cells disrupts differentiation of germline stem cells in the Drosophila ovary.
    3. cullin-5 and cullin-2 play a role in the development of neuromuscular junction and the female germ line of Drosophila
      Title: Cullin-5 and cullin-2 play a role in the development of neuromuscular junction and the female germ line of Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein-macromolecule adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin ligase complex scaffold activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin protein ligase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in germ cell development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in growth of a germarium-derived egg chamber IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in male germ-line cyst encapsulation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of BMP signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of BMP signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of receptor signaling pathway via JAK-STAT IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in regulation of synaptic assembly at neuromuscular junction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in viral process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Cul2-RING ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Cul2-RING ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Cul2-RING ubiquitin ligase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of SCF ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cullin-RING ubiquitin ligase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cullin 2
    Names
    CG1512-PA
    CG1512-PB
    Cul2-PA
    Cul2-PB
    Cullin-2
    cul-2
    cullin2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      21658735..21663698
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_165390.2 → NP_724352.1  cullin 2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724352.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95RE8, Q9V9R2
      Related
      FBpp0085254
      Conserved Domains (3) summary
      smart00182
      Location:436 → 575
      CULLIN; Cullin
      smart00884
      Location:680 → 745
      Cullin_Nedd8; Cullin protein neddylation domain
      pfam00888
      Location:39 → 639
      Cullin; Cullin family

    2. NM_136273.3 → NP_610117.1  cullin 2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610117.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95RE8, Q9V9R2
      Related
      FBpp0085255
      Conserved Domains (3) summary
      smart00182
      Location:436 → 575
      CULLIN; Cullin
      smart00884
      Location:680 → 745
      Cullin_Nedd8; Cullin protein neddylation domain
      pfam00888
      Location:39 → 639
      Cullin; Cullin family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9V9R2 Q9V9R2

    Gene LinkOut

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