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    SLC22A SLC22A family member [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40437, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SLC22Aprovided by FlyBase
    Official Full Name
    SLC22A family memberprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037140
    Locus tag
    Dmel_CG7442
    See related
    AllianceGenome:FB:FBgn0037140
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG7442; Dmel\CG7442; DmSLC22A; Slc22a15
    Summary
    Enables choline transmembrane transporter activity. Involved in several processes, including acetylcholine transport; negative regulation of cholinergic synaptic transmission; and regulation of olfactory learning. Predicted to be located in membrane. Is expressed in Kenyon cell; adult head; adult optic lobe glial cell; synaptic neuropil domain; and tract. Orthologous to human SLC22A1 (solute carrier family 22 member 1) and SLC22A3 (solute carrier family 22 member 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See SLC22A in Genome Data Viewer
    Location:
    79A4-79A4; 3-47 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (21934704..21938636)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (21927804..21931736)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene mushroom-body expressed Neighboring gene long non-coding RNA:CR43878 Neighboring gene long non-coding RNA:CR45959 Neighboring gene long non-coding RNA:CR45803 Neighboring gene uncharacterized protein Neighboring gene DNA polymerase eta Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila SLC22A Transporter Is a Memory Suppressor Gene that Influences Cholinergic Neurotransmission to the Mushroom Bodies. Gai Y, et al. Neuron, 2016 May 4. PMID 27146270, Free PMC Article
    2. Learning and memory using Drosophila melanogaster: a focus on advances made in the fifth decade of research. Davis RL. Genetics, 2023 Aug 9. PMID 37212449, Free PMC Article
    3. Drosophila SLC22 Orthologs Related to OATs, OCTs, and OCTNs Regulate Development and Responsiveness to Oxidative Stress. Engelhart DC, et al. Int J Mol Sci, 2020 Mar 15. PMID 32183456, Free PMC Article
    4. The β-alanine transporter BalaT is required for visual neurotransmission in Drosophila. Han Y, et al. Elife, 2017 Aug 14. PMID 28806173, Free PMC Article
    5. The Proton-Coupled Monocarboxylate Transporter Hermes Is Necessary for Autophagy during Cell Death. Velentzas PD, et al. Dev Cell, 2018 Nov 5. PMID 30318245, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: 21935901-21936032 mobile_element_type = transposon:INE-1{}2148

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables choline transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in acetylcholine transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in memory IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of synaptic transmission, cholinergic IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of olfactory learning IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    SLC22A family member
    Names
    CG7442-PA
    SLC22A-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      21934704..21938636
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141113.3 → NP_649370.1  SLC22A family member [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649370.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VNX2
      Related
      FBpp0078124
      Conserved Domains (2) summary
      cd06174
      Location:146 → 530
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR00898
      Location:35 → 540
      2A0119; cation transport protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VNX2 Q9VNX2

    Gene LinkOut

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