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    t tan [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31863, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tprovided by FlyBase
    Official Full Name
    tanprovided by FlyBase
    Primary source
    FLYBASE:FBgn0086367
    Locus tag
    Dmel_CG12120
    See related
    AllianceGenome:FB:FBgn0086367
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG12120; Dmel\CG12120; Tan
    Summary
    Enables beta-alanyl-dopamine hydrolase activity and beta-alanyl-histamine hydrolase activity. Involved in several processes, including cuticle pigmentation; dopamine biosynthetic process; and histamine biosynthetic process. Located in cytosol. Is expressed in several structures, including adult brain; anterior-posterior subdivision of organism; eye; photoreceptor neurons; and synaptic neuropil domain. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    Location:
    8D1-8D1; 1-27 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (9217655..9223257, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (9111688..9117290, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Gustatory receptor 8a Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sensitivity of Allelic Divergence to Genomic Position: Lessons from the Drosophila tan Gene. John AV, et al. G3 (Bethesda), 2016 Sep 8. PMID 27449514, Free PMC Article
    2. Strong epistatic and additive effects of linked candidate SNPs for Drosophila pigmentation have implications for analysis of genome-wide association studies results. Gibert JM, et al. Genome Biol, 2017 Jul 3. PMID 28673357, Free PMC Article
    3. Abnormal concentrations of dopamine in a Drosophila mutant. Konopka RJ. Nature, 1972 Sep 29. PMID 4627779
    4. Separation of receptor and lamina potentials in the electroretinogram of normal and mutant Drosophila. Heisenberg M. J Exp Biol, 1971 Aug. PMID 5001616
    5. On-transient of insect electroretinogram: its cellular origin. Alawi AA, et al. Science, 1971 Jun 4. PMID 5573957

    See all (111) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Here, we test this assumption by comparing the activity of tan alleles from two Drosophila species, D. americana and D. novamexicana, at five different genomic locations in D. melanogaster We found that the relative effects of these alleles varied among insertion sites, with no difference in activity observed between them at two sites
      Title: Sensitivity of Allelic Divergence to Genomic Position: Lessons from the Drosophila tan Gene.
    2. Interestingly, t was previously shown to be involved in inter-individual variation of female abdominal pigmentation in Drosophila melanogaster, and in abdominal pigmentation divergence between Drosophila species. Sensitivity of t expression to environmental conditions might therefore give more substrate for selection, explaining why this gene has frequently been involved in evolution of pigmentation.
      Title: Phenotypic Plasticity through Transcriptional Regulation of the Evolutionary Hotspot Gene tan in Drosophila melanogaster.
    3. D. melanogaster CG12120 corresponds to tan, a novel hydrolase required in pigmentation and vision
      Title: Drosophila tan encodes a novel hydrolase required in pigmentation and vision.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables beta-alanyl-dopamine hydrolase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables beta-alanyl-dopamine hydrolase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables beta-alanyl-histamine hydrolase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables hydrolase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cuticle pigmentation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in dopamine biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in histamine biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in histamine metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in visual perception IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tan
    Names
    CG12120-PA
    CG12120-PB
    Tan
    beta-alanyl-dopamine hydrolase
    on-transient defective
    t-PA
    t-PB
    NP_001285042.1
    NP_572543.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      9217655..9223257 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132315.1 → NP_572543.1  tan, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572543.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9W369
      UniProtKB/TrEMBL
      D7RHE8
      Related
      FBpp0071270, FBtr0071335
      Conserved Domains (1) summary
      pfam03417
      Location:127 → 375
      AAT; Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase

    2. NM_001298113.1 → NP_001285042.1  tan, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285042.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9W369
      UniProtKB/TrEMBL
      D7RHE8
      Conserved Domains (1) summary
      pfam03417
      Location:127 → 375
      AAT; Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W369.1 Q9W369

    Gene LinkOut

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