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    SrpRalpha Signal recognition particle receptor alpha [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 47251, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SrpRalphaprovided by FlyBase
    Official Full Name
    Signal recognition particle receptor alphaprovided by FlyBase
    Primary source
    FLYBASE:FBgn0010391
    Locus tag
    Dmel_CG2522
    See related
    AllianceGenome:FB:FBgn0010391
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BEST:CK00309; CG2522; CK00309; Dmel\CG2522; Gtp-bp; GTP-bp; mAb 13D5
    Summary
    Predicted to enable GTPase activity and signal recognition particle binding activity. Involved in axonogenesis and regulation of protein secretion. Located in endoplasmic reticulum membrane. Is expressed in several structures, including embryonic/larval midgut primordium; epidermis; gland; gut section; and nerve. Orthologous to human SRPRA (SRP receptor subunit alpha). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See SrpRalpha in Genome Data Viewer
    Location:
    10A6-10A6; 1-33 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (11126877..11129087, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (11020910..11023120, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Regulatory particle triple-A ATPase 3 Neighboring gene Kinesin-like protein at 10A Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR44054 Neighboring gene CDK2-associated protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of a putative Drosophila GTP-binding protein. Fredieu JR, et al. J Cell Sci, 1993 May. PMID 8360279
    2. An orchestrated program regulating secretory pathway genes and cargos by the transmembrane transcription factor CREB-H. Barbosa S, et al. Traffic, 2013 Apr. PMID 23279168, Free PMC Article
    3. Retroactive, a membrane-anchored extracellular protein related to vertebrate snake neurotoxin-like proteins, is required for cuticle organization in the larva of Drosophila melanogaster. Moussian B, et al. Dev Dyn, 2005 Jul. PMID 15844167
    4. RNAi experiments in D. melanogaster: solutions to the overlooked problem of off-targets shared by independent dsRNAs. Seinen E, et al. PLoS One, 2010 Oct 1. PMID 20957038, Free PMC Article
    5. The CrebA/Creb3-like transcription factors are major and direct regulators of secretory capacity. Fox RM, et al. J Cell Biol, 2010 Nov 1. PMID 21041443, Free PMC Article

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables signal recognition particle binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables signal recognition particle binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in SRP-dependent cotranslational protein targeting to membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in axonogenesis IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein targeting to ER IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of protein secretion IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endomembrane system HDA PubMed 
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of signal recognition particle receptor complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    signal recognition particle receptor alpha
    Names
    CG2522-PA
    GTP binding protein
    GTP-binding protein
    SrpRalpha-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      11126877..11129087 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_080148.3 → NP_524887.2  signal recognition particle receptor alpha [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524887.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q95RJ8, Q9U5L1, Q9VZ29
      UniProtKB/TrEMBL
      B5RIS4
      Related
      FBpp0073336
      Conserved Domains (4) summary
      smart00963
      Location:299 → 374
      SRP54_N; SRP54-type protein, helical bundle domain
      PRK14974
      Location:258 → 613
      PRK14974; cell division protein FtsY; Provisional
      cd03115
      Location:396 → 592
      SRP; The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The ...
      pfam04086
      Location:27 → 268
      SRP-alpha_N; Signal recognition particle, alpha subunit, N-terminal
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9U5L1.2 Q9U5L1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
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