Khc-73 Kinesin heavy chain 73 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Khc-73provided by FlyBase
Official Full Name: Kinesin heavy chain 73provided by FlyBase
Primary source: FLYBASE:FBgn0019968
Locus tag: Dmel_CG8183
See related: AllianceGenome:FB:FBgn0019968
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-EST:fe3C9; CG8183; Dmel\CG8183; DmKin73; DmKIN73; DmKlp73; Khc 73; khc-73; KHC-73; khc73; Khc73; KIF 13A; KIF13A/B; Kin73; Kinesin-73; KLP73
Summary: Enables microtubule motor activity and protein homodimerization activity. Involved in establishment of spindle orientation; regulation of olfactory learning; and regulation of synapse structure or activity. Located in early endosome and microtubule plus-end. Colocalizes with astral microtubule. Is expressed in spermatozoon. Orthologous to several human genes including KIF13A (kinesin family member 13A). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 52A6-52A10; 2-74 cM

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (15515778..15532259, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (11403283..11419764, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Khc-73 as a regulator of endosomal traffic at the synapse and modulator of retrograde BMP signaling in motoneurons.
Title: Kinesin Khc-73/KIF13B modulates retrograde BMP signaling by influencing endosomal dynamics at the Drosophila neuromuscular junction.
The Khc73 stalk/14-3-3/NudE pathway defines a physical connection that coordinates the activities of multiple motor proteins to precisely position the spindle.
Title: A NudE/14-3-3 pathway coordinates dynein and the kinesin Khc73 to position the mitotic spindle.
the N-terminal half of Khc-73 can undergo a monomer-dimer transition to produce a fast processive motor and that its C-terminal half possesses a specific Rab5-vesicle binding domain
Title: Kinesin-73 is a processive motor that localizes to Rab5-containing organelles.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm1631 (e-PCR)
- UniSTS:63276

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	IEA Inferred from Electronic Annotation more info
enables microtubule motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule motor activity	IDA Inferred from Direct Assay more info	PubMed
enables microtubule motor activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in establishment of spindle orientation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in microtubule-based movement	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule-based movement	IEA Inferred from Electronic Annotation more info
involved_in regulation of olfactory learning	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of synapse structure or activity	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
colocalizes_with astral microtubule	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in early endosome	IDA Inferred from Direct Assay more info	PubMed
part_of kinesin complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in microtubule plus-end	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: kinesin heavy chain 73

Names: CG8183-PA; CG8183-PC; CG8183-PD; CG8183-PE; CG8183-PF; Khc-73-PA; Khc-73-PC; Khc-73-PD; Khc-73-PE; Khc-73-PF; Kinesin-3; Kinesin-73; Kinesin3B; anon-fast-evolving-3C9; kinesin heavy-chain 73

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

15515778..15532259 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001274070.2 → NP_001260999.1 kinesin heavy chain 73, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001260999.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KG24, O01349

Conserved Domains (7) summary

smart00129
Location:4 → 330

KISc; Kinesin motor, catalytic domain. ATPase

cd00060
Location:417 → 517

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd01365
Location:1 → 330

KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins

pfam01302
Location:1795 → 1859

CAP_GLY; CAP-Gly domain

pfam12423
Location:712 → 757

KIF1B; Kinesin protein 1B

pfam12473
Location:1167 → 1223

DUF3694; Kinesin protein

pfam16183
Location:327 → 439

Kinesin_assoc; Kinesin-associated
NM_176176.3 → NP_788356.2 kinesin heavy chain 73, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_788356.2

Status: REVIEWED

UniProtKB/TrEMBL

A4UZI0, O01349

Conserved Domains (7) summary

smart00129
Location:6 → 359

KISc; Kinesin motor, catalytic domain. ATPase

cd00060
Location:446 → 546

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd01365
Location:4 → 359

KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins

pfam01302
Location:1786 → 1850

CAP_GLY; CAP-Gly domain

pfam12423
Location:741 → 786

KIF1B; Kinesin protein 1B

pfam12473
Location:1196 → 1252

DUF3694; Kinesin protein

pfam16183
Location:356 → 468

Kinesin_assoc; Kinesin-associated
NM_001274071.2 → NP_001261000.1 kinesin heavy chain 73, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261000.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KFR5, O01349

Conserved Domains (7) summary

smart00129
Location:6 → 359

KISc; Kinesin motor, catalytic domain. ATPase

cd00060
Location:446 → 546

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd01365
Location:4 → 359

KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins

pfam01302
Location:1786 → 1850

CAP_GLY; CAP-Gly domain

pfam12423
Location:741 → 786

KIF1B; Kinesin protein 1B

pfam12473
Location:1196 → 1252

DUF3694; Kinesin protein

pfam16183
Location:356 → 468

Kinesin_assoc; Kinesin-associated
NM_001299533.1 → NP_001286462.1 kinesin heavy chain 73, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001286462.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4LGK5, O01349

Conserved Domains (7) summary

smart00129
Location:6 → 359

KISc; Kinesin motor, catalytic domain. ATPase

cd00060
Location:446 → 546

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd01365
Location:4 → 359

KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins

pfam01302
Location:1800 → 1864

CAP_GLY; CAP-Gly domain

pfam12423
Location:741 → 800

KIF1B; Kinesin protein 1B

pfam12473
Location:1210 → 1266

DUF3694; Kinesin protein

pfam16183
Location:356 → 468

Kinesin_assoc; Kinesin-associated
NM_135357.5 → NP_609201.3 kinesin heavy chain 73, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_609201.3

Status: REVIEWED

UniProtKB/TrEMBL

A1ZA18, O01349

Related

FBpp0086490

Conserved Domains (7) summary

smart00129
Location:6 → 359

KISc; Kinesin motor, catalytic domain. ATPase

cd00060
Location:446 → 546

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd01365
Location:4 → 359

KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins

pfam01302
Location:1808 → 1872

CAP_GLY; CAP-Gly domain

pfam12423
Location:741 → 800

KIF1B; Kinesin protein 1B

pfam12473
Location:1210 → 1266

DUF3694; Kinesin protein

pfam16183
Location:356 → 468

Kinesin_assoc; Kinesin-associated