Su(Tpl) Suppressor of Triplolethal [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Su(Tpl)provided by FlyBase
Official Full Name: Suppressor of Triplolethalprovided by FlyBase
Primary source: FLYBASE:FBgn0014037
Locus tag: Dmel_CG32217
See related: AllianceGenome:FB:FBgn0014037
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 0854/01; CG32217; CG8037; CR32216; dEll; dELL; Dmel\CG32217; Ell; ELL; l (3)76BD; l(3)76BDs; l(3)S000606; l(3)S085401; SR3-4A; SS3-4; Su(Tpl)/; SY3-1
Summary: Enables RNA polymerase binding activity and chromatin binding activity. Involved in several processes, including neuronal stem cell population maintenance; positive regulation of transcription elongation by RNA polymerase II; and snRNA transcription by RNA polymerase II. Located in euchromatin; nucleolus; and polytene chromosome puff. Part of transcription elongation factor complex. Is active in chromatin. Is expressed in adult brain cell body rind; adult optic lobe; and type II neuroblast. Orthologous to several human genes including ELL (elongation factor for RNA polymerase II) and ELL2 (elongation factor for RNA polymerase II 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (19889120..19909410, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (19882220..19902510, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

elongation factor ELL protein regulates the transcription activvity of RNA polymerase II
Title: Regulation of the transcriptional activity of poised RNA polymerase II by the elongation factor ELL.
Drosophila ELL has an essential activity in development distinct from its role as an RNA polymerase II elongation factor
Title: Mutational analysis of an RNA polymerase II elongation factor in Drosophila melanogaster.
an essential RNA polymerase II elongation factor with a general role in development
Title: dELL is an essential RNA polymerase II elongation factor with a general role in development.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables RNA polymerase binding	IDA Inferred from Direct Assay more info	PubMed
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to heat	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuronal stem cell population maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription elongation by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription elongation by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in snRNA transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in snRNA transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transcription elongation by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in wing disc dorsal/ventral pattern formation	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in chromatin	IDA Inferred from Direct Assay more info	PubMed
located_in euchromatin	IMP Inferred from Mutant Phenotype more info	PubMed
located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	HDA more info	PubMed
located_in polytene chromosome puff	IDA Inferred from Direct Assay more info	PubMed
part_of transcription elongation factor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of transcription elongation factor complex	IDA Inferred from Direct Assay more info	PubMed
part_of transcription elongation factor complex	IEA Inferred from Electronic Annotation more info

Names: CG32217-PA; CG32217-PB; CG32217-PC; Su(Tpl)-PA; Su(Tpl)-PB; Su(Tpl)-PC; eleven-nineteen lysine-rich leukemia; elongation factor RNA polymerase II; suppressor of GMR-sina 3-4

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