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    CG3603 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31289, updated on 27-Dec-2024

    Summary

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    Official Symbol
    CG3603provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0029648
    Locus tag
    Dmel_CG3603
    See related
    AllianceGenome:FB:FBgn0029648
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:RH09070; Dmel\CG3603
    Summary
    Predicted to enable 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity and quinone binding activity. Predicted to be involved in fatty acid biosynthetic process. Predicted to be located in mitochondrial matrix. Is expressed in adult head; adult heart; and organism. Orthologous to human HSD17B8 (hydroxysteroid 17-beta dehydrogenase 8). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG3603 in Genome Data Viewer
    Location:
    3C3-3C3; 1-2 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (2948034..2949120)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (2842067..2843153)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene kin of irre Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene roughest Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. High-resolution mapping of heterochromatin redistribution in a Drosophila position-effect variegation model. Vogel MJ, et al. Epigenetics Chromatin, 2009 Jan 29. PMID 19178722, Free PMC Article
    2. Relish-facilitated lncRNA-CR11538 suppresses Drosophila Imd immune response and maintains immune homeostasis via decoying Relish away from antimicrobial peptide promoters. Huang Y, et al. Dev Comp Immunol, 2024 Feb. PMID 37956726
    3. Cdk8 attenuates lipogenesis by inhibiting SREBP-dependent transcription in Drosophila. Li X, et al. Dis Model Mech, 2022 Nov 1. PMID 36305265, Free PMC Article
    4. Metabolic regulation of proteome stability via N-terminal acetylation controls male germline stem cell differentiation and reproduction. François CM, et al. Nat Commun, 2023 Oct 23. PMID 37872135, Free PMC Article
    5. Genome-wide transcription profile of field- and laboratory-selected dichlorodiphenyltrichloroethane (DDT)-resistant Drosophila. Pedra JH, et al. Proc Natl Acad Sci U S A, 2004 May 4. PMID 15118106, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables quinone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in fatty acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG3603-PA
    CG3603-PB
    NP_001259199.1
    NP_570046.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      2948034..2949120
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001272270.1 → NP_001259199.1  uncharacterized protein Dmel_CG3603, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259199.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B4F625, Q9W4U2
      Conserved Domains (2) summary
      cd05333
      Location:9 → 248
      BKR_SDR_c; beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs
      PRK05653
      Location:6 → 248
      fabG; 3-ketoacyl-(acyl-carrier-protein) reductase; Validated

    2. NM_130690.3 → NP_570046.1  uncharacterized protein Dmel_CG3603, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_570046.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B4F625, Q9W4U2
      Related
      FBpp0070533
      Conserved Domains (2) summary
      cd05333
      Location:9 → 248
      BKR_SDR_c; beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs
      PRK05653
      Location:6 → 248
      fabG; 3-ketoacyl-(acyl-carrier-protein) reductase; Validated
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W4U2 Q9W4U2

    Gene LinkOut

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